羟考酮与地佐辛配伍丙泊酚在无痛清宫术中的效果比较

Comparison of effect between oxycodone and dezocine by compatibility with propofol in painless uterine curettage

目的通过观察羟考酮与地佐辛配伍丙泊酚在无痛清宫术中的效果,探讨一种更安全舒适的麻醉方法 ,以满足无痛清宫术的麻醉需求。方法 200例自愿采用无痛方式进行清宫术的患者随机双盲分成丙泊酚复合羟考酮组(Q组)、丙泊酚复合地佐辛组(D组),每组100例。记录两组患者麻醉诱导前(T1)、麻醉后2 min(T2)、吸宫时(T3)、术毕(T4)时平均动脉压(MAP)、心率(HR)、脉搏血氧饱和度(Sp O2),以及离室时间、术后腹痛(子宫收缩痛)的视觉模拟评分(VAS)。结果 T1、T2、T3、T4时MAP、HR、Sp O2值两组组间比较差异无统计学意义(P>0.05);两组MAP、HR和Sp O2均在T2时间点出现下降,其中MAP与T1时刻比较差异有统计学意义(P<0.05);T3和T4时间点,MAP、HR和Sp O2的变化与T1时刻比较差异无统计学意义(P>0.05)。两组患者的离室时间比较差异无统计学意义(P>0.05);术后10 min两组VAS评分比较,差异有统计学意义(P<0.05)。结论在无痛清宫术中,羟考酮复合丙泊酚治疗术后子宫收缩痛较轻,麻醉效果较地佐辛好。

Objective To investigate a safe and comfortable anesthesia method by observing effects of oxycodone and dezocine by compatibility with propofol in painless uterine curettage to meet anesthesia need in painless uterine curettage. Methods A total of 200 voluntary patients receiving painless uterine curettage were divided by random double-blind method into propofol combined with oxycodone group（group Q） and propofol combined with dezocine group（group D）, with 100 cases in each group. Their mean arterial pressure（MAP）, heart rate（HR）, saturation of pulse oximetry（Sp O2）, and visual analogue scale（VAS） scores of leave time and postoperative abdominal pain（uterine contraction pain） before anesthesia induction（T1）, in 2 min after anesthesia（T2）, during uterine aspiration（T3）, and at the end of operation（T4） were all recorded. Results There was no statistically significant difference of MAP, HR and Sp O2 in T1, T2, T3, and T4 between the two groups（P〉0.05）. Both groups had decreased MAP, HR and Sp O2 in T2, and difference of MAP from that in T1 had statistical significance（P〈0.05）. The differences of MAP, HR and Sp O2 in T3 and T4 had no statistical significance with those in T1（P〉0.05）. There was no statistical significance in difference of leave time between the two groups（P〉0.05）. Their VAS scores in postoperative 10 min had statistically significant difference（P〈0.05）. Conclusion Implement of oxycodone combined with propofol in painless uterine curettage provides slighter postoperative uterine contraction pain and better anesthetic effect than dezocine.