妊娠期妇女在不同孕期血清铁蛋白、叶酸和25羟基维生素D检测的临床意义

Clinical significance of serum ferritin, folic acid and 25-hydroxyitamin D detection in pregnant women during different duration

目的了解妊娠期妇女在不同孕期血清铁蛋白(SF)、叶酸(FA)和25羟基维生素D(25OHD)检测的意义。方法运用化学发光免疫分析法检测150例作产前保健的孕妇(妊娠组)、55例无贫血症状健康妊娠妇女(对照2组)在不同孕期及55例健康体检合格的非妊娠妇女(对照1组)的SF、FA和25OHD含量。结果随着孕期的增加三项的含量都逐渐下降,与对照组相比,妊娠组早孕的SF、25OHD较低,差异具有统计学意义(P<0.05),FA比较差异无统计学意义(P>0.05),中、晚期的SF、FA和25OHD含量均比对照组低,差异具有统计学意义(P<0.01)。随着孕期的增加,SF和FA低下检出率逐渐升高,差异具有统计学意义(P<0.05)。结论检测妊娠期妇女在不同孕期SF、FA和25OHD含量可以对妊娠期贫血的防治提供帮助,保障母婴安全。

Objective To understand significance of serum ferritin（SF）, folic acid（FA） and 25-hydroxyitamin D（25OHD） detection in pregnant women during different duration. Methods Chemiluminescence immunoassay was applied to detect SF, FA, and 25 OHD contents in 150 pregnant women receiving prenatal care（pregnancy group）, 55 healthy pregnant women without anemia（control group 2）, and 55 healthy non-pregnant women（control group 1）. Results Contents of the three indexes decreased along with progress of pregnancy. Comparing with the control groups, the pregnancy group had lower SF and 25 OHD in early pregnancy, and their difference had statistical significance（P〈0.05）. Their difference of FA had no statistical significance（P〉0.05）. Moderate and late pregnancy had all lower SF, FA and 25 OHD than the control groups, and their difference had statistical significance（P〈0.01）. Detection rate of SF and FA deficiency increased gradually along with progress of pregnancy, and the difference had statistical significance（P〈0.05）. Conclusion Detection of SF, FA, and 25 OHD in pregnant women during different duration is helpful to prevent anemia during pregnancy and guarantee maternal and neonatal safety.