同步放化疗在宫颈癌治疗中的疗效及安全性观察

Observation of curative effect and safety of concurrent radiochemotherapy in treatment of cervical cancer

目的探讨同步放化疗在宫颈癌治疗中的临床疗效及安全性。方法 262例宫颈癌患者,采用随机数表法将其分为观察组与对照组,每组131例,对照组患者术前接受单纯放疗,观察组患者术前行同步放化疗,比较两组患者放化疗前后肿块消退及不良反应发生情况。结果观察组患者同步放化疗后术前肿块体积明显较对照组患者放疗后缩小,而术后病理显示观察组宫颈浸润程度明显低于对照组,差异具有统计学意义(P<0.05);术前观察组骨髓抑制、胃肠道反应等不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论对局部中晚期宫颈癌患者术前行同步放化疗可有效缩小肿块体积,并可降低患者宫颈浸润程度,同时应用安全性较高,具有临床应用及推广价值。

Objective To investigate clinical effect and safety of concurrent radiochemotherapy in treatment of cervical cancer. Methods A total of 262 patients with cervical cancer were divided by random number table into observation group and control group, with 131 cases in each group. The control group received single preoperative radiotherapy, and the observation group received preoperative concurrent radiochemotherapy. Comparisons were made on tumor regression and adverse reactions between the two groups before and after radiochemotherapy. Results The observation group had much smaller tumor size than the control group after radiochemotherapy, and postoperative pathology showed the observation group had obviously lower cervical infiltration degree than the control group. Their difference had statistical significance（P〈0.05）. Incidence of adverse reactions, such as myelosuppression and gastrointestinal reaction, had no statistically significant difference before operation between the two groups（P〉0.05）. Conclusion Implement of concurrent radiochemotherapy for local middle-late cervical cancer patients can effectively reduce tumor size and cervical infiltration degree, with good safety in application. This method contains value for clinical application and promotion.