摘要
目的探讨子宫内膜癌合并2型糖尿病血清脂联素水平的变化及意义。方法采用回顾性分析方法比较子宫内膜癌合并2型糖尿病(A组)、单纯子宫内膜癌(B组)、健康体检者(C组)血清脂联素的水平。ELISA法测定3组血清脂联素水平,并分析其与A组各临床病理参数之间的关系。结果 A组脂联素的水平(5.55mg/L±0.68mg/L)低于B组(5.97mg/L±0.57mg/L)及C组(15.32mg/L±0.42mg/L),差异有统计学意义(P<0.05);B组低于C组,差异有统计学意义(P<0.05)。根据A组术后病理分析脂联素水平与分期、分级及淋巴结转移有关,差异有统计学意义(P<0.05)。结论子宫内膜癌合并2型糖尿病血清脂联素水平较单纯子宫内膜癌及健康体检者低,且与分期、分级及淋巴结转移有关。因此血清脂联素水平检测对于探讨子宫内膜癌合并2型糖尿病的发病原因及预后评估具有一定价值。
Objective To explore the changes and clinical significents of serum adiponectin levels in endometrial cancer with type 2 diabetic patients.Methods Compared the levels of serum adiponectin in endometrial cancer with type 2 diabetic patients（ Group A） , simple endometrial cancer patients（ Group B） and healthy people（ Group C） by using the method of retrospective analysis.Determined serum adiponectin levels of the three groups were detected by ELISA,and analyzed their relationship with clinicopathological parameters of Group A. Results Serum adiponectin levels in Group A（5.55mg/L ±0.68mg/L） were lower than those in Group B（5.97mg/L ±0.57mg/L） and Group C（15.32mg/L ±0.42mg/L）,and the differences were statistically significant;Serum adiponectin levels in Group B were lower than those in Group C,the difference was statistically significant;According to the pathology of Group A,we found that serum adiponectin levels had relationship with the stage,grade and lymph node metastasis.Conclusion Serum adiponectin level in endometrial cancer with Type 2 Diabetic are lower than that in simple endometrial cancer and healthier,and it has a relationship with the stage,grade and lymph node metas-tasis.So detection of serum adiponectin levels have values for the causes and prognosis of endometrial cancer with Type 2 diabetic.
出处
《潍坊医学院学报》
2015年第6期422-423,共2页
Acta Academiae Medicinae Weifang
