血清氧化型低密度脂蛋白水平对颈动脉粥样硬化斑块稳定性的诊断价值

The diagnostic value of serum oxLDL for carotid atherosclerotic plaque stability

目的 :探讨血清氧化型低密度脂蛋白(oxLDL)水平对颈动脉粥样硬化斑块稳定性的诊断价值。方法:选取2013年10月至2014年4月在本院内科收治的住院患者中经颈动脉超声检查确诊为动脉粥样硬化斑块者130例,根据彩色多普勒超声检查结果分为动脉粥样硬化稳定斑块组、动脉粥样硬化不稳定斑块组;选取同期在本院体检中心行颈动脉超声检查的120例健康体检者作为对照组(无斑块者),同时检测受试者清晨血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及oxLDL水平。结果:3组间oxLDL水平的差异有统计学意义(F=213.11,P<0.001)。经两两比较得出,不稳定斑块组高于稳定斑块组和正常组,稳定斑块组高于正常组。oxLDL所绘制ROC曲线下面积为0.808(P<0.001)。结论:血清oxLDL水平对颈动脉粥样硬化斑块稳定性的诊断具有一定的临床价值。

Objective：This study was designed to investigate the diagnostic value of serum oxidized low density lipoprotein（ox LDL） for carotid atherosclerotic plaque stability. Methods：From Oct.2013 to Apr.2014,we enrolled 130 patients with carotid atherosclerotic plaque as the study group. All these patients were further divided into the unstable atherosclerotic plaque group and the stable atherosclerotic plaque group according to the results of color Doppler ultrasonography. Meanwhile,120 people receiving physical examination in medical examination room and diagnosed with no carotid atherosclerotic plaque were recruited as the control group. The levels of serum TC,LDL-C and ox LDL were examined in all 250 patients. Results：The difference of serum ox LDL level among three groups was statistically significant（F =213.11,P〈 0.001）. The level of serum ox LDL was much higher in the unstable atherosclerotic plaque group than that of the stable atherosclerotic plaque group,and was lowest in the control group. The area under ROC curve about ox LDL were 0.863（P〈 0.01）. Conclusion：The level of serum ox LDL has the diagnostic value for the stability of carotid atherosclerotic plaque.