探讨盐酸多奈哌齐治疗老年痴呆患者的临床疗效

Treatment of Elderly Patients With Dementia

目的探讨分析盐酸多奈哌齐治疗老年痴呆患者的临床疗效。方法将我院收治的100例老年痴呆患者随机分为观察组和对照组,每组为50例,观察组利用盐酸对奈哌齐治疗,而对照组患者的治疗运用吡拉西坦,对比两组患者的临床疗效。结果观察组临床有效率为92%,高于对照组的72%,差异具有统计学意义(P<0.05);治疗后,两组患者的智能精神量表(MMSE)评分和生活活动能力量表(ADL)评分均改善,且观察组改善优于对照组(P<0.05)。结论利用盐酸多奈哌齐治疗老年痴呆患者可有效改善精神状态,提升生活能力,临床疗效较好。

Objective To investigate the clinical value of donepezil hydrochloride in the treatment of patients with senile dementia. Methods 100 cases of senile dementia patients were randomly divided into observation group and control group in our hospital, each group of 50 cases, observation group using hydrochloric acid to treatment, and control group in the treatment of patients with using pyrazole raschig, compared two groups of clinical curative effect. Results Clinical observation group efficiency reached 92%, significantly higher than that of control group 72%the difference is statistically significant（P〈0.05）. After treatment,of both the two groups, mini-mental state exanmination（MMSE） and activities of daily living scale（ADL） scores were improved, but the observation group improved better than that of control group（P〈0.05）. Conclusion Use of donepezil hydrochloride treatment of alzheimer＇s patients effectively improve mental state, improving the ability of life, clinical curative effect is remarkable.