采用米非司酮联合甲氨蝶呤治疗宫外孕的疗效观察

Effect of mifepristone combined with methotrexate in the treatment of ectopic pregnancy

目的探讨米非司酮联合甲氨蝶呤治疗宫外孕的疗效。方法选取我院2013年5月~2014年6月收治的宫外孕患者117例作为研究对象,按用药不同分为A、B、C三组。A组患者给予米非司酮治疗,B组患者给予甲氨蝶呤治疗,C组患者采取二者联合用药治疗。观察三组患者的疗效及不良反应发生情况。结果三组患者疗效均良好,其中C组患者治愈率明显高于A组和B组,差异有统计学意义（P〈0.05）;三组患者在血人绒毛膜促性腺激素（β-HCG）浓度恢复正常时间、阴道排出蜕膜管型时间、尿β-HCG转阴时间及症状完全消失时间对比,差异有统计学意义（P〈0.05）。结论米非司酮联合甲氨蝶呤治疗血β-HCG浓度较低的宫外孕患者疗效显著,同时不良反应发生率低,值得临床推广。

Objective To investigate the effect of mifepristone combined with methotrexate in the treatment of patients with ectopic pregnancy. Methods Choosed 117 cases of extrauterine pregnancy patients from May. 2013 to Jun. 2014 to divide into A, B, C group. The A group were treated with mifepristone, B group were treated with methotrexate, C group were treated with these two medicines. Observed the effect of these three groups and adverse effects. Results The effect of C group was better than A,B groups（P〈0.05）.The recovery time of β-HCG, time of discharging decidual cast, and symptom disappearing time had difference（P〈0.05）. Conclusion Treating extrauterine pregnancy with mifepristone and methotrexate is effective with less adverse effects to extend in clinic.