登革热极期并肝损害治疗用药的各因素分析

Factors Analysis of Medication on Patients at Critical Period of Dengue Fever with Liver Injury

目的分析登革热(DF)极期并肝损害治疗用药的各因素。方法选取2014年某病区登革热患者,分析其中处于极期患者的肝损害情况,统计分析肝损程度与疾病治疗各因素的相关性。结果在极期,DF并肝损害发生率80.2%,且住院天数和重症登革热(SD)发生率与未合并肝损害患者相比有显著性差异;SD与典型登革热比较,WBC无显著性差异,ALT差异不明显,但AST差异显著;护肝药物对登革热并肝损害患者治疗效果确定,但与护肝药物品种没有相关性,达到一定治疗效果后,药物使用强度的增加并未加强疗效。结论登革热极期患者要充分考虑肝损,因为肝损程度加重引起住院天数增加,但要预防过度治疗。

OBJECTIVE To analyze the factors of medication on patients at the critical period of dengue fever with liver injury.METHODS All the patients with dengue fever hospitalized in one ward in 2014 were selected,the liver injury situation of those patients at the critical period of dengue fever were analyzed,and the correlation between the level of liver injury and other factors of clinical treatment was analyzed. RESULTS At the critical period of dengue fever,the incidence of liver injury was 80. 2%. It was significantly different in the days of hospitalization and the rate of SD occurrence between patients with and without liver injury.Compared to the common dengue fever,WBC and ALT values of SD were no significant difference,except AST value. Though liver protective drugs made certain medication effect on patients with dengue fever and liver injury,there was no correlation between the medication effect and the class of liver protective drugs,after reaching uncertain effect of medication,the increasing of use intensity wouldn＇t increase the effect any more. CONCLUSION Liver injury should be considered thoroughly on the patients at the critical period of dengue fever,because the aggravation of liver injury can increase the days of hospitalization. However,over-medication should be prevented.