前列地尔在断指再植中的临床应用研究

Clinical Application of Alprostadil in Replantation of Amputated Fingers

目的探讨前列地尔在断指再植术后预防血管危象的临床疗效。方法收集本院2014-01~2015-03期间60例断指再植术后患者,随机等分为2组,除基础治疗外,实验组使用罂粟碱＋前列地尔,对照组使用罂粟碱＋肝素,观察术后1周2组管危象发生的情况,毛细血管反应情况,术后1周的完全存活率等指标。结果实验组术后再植指体29例存活良好,1例坏死,存活率96.7%。对照组术后再植指体28例存活良好,2例发生坏死,存活率93.3%。2组之间无显著性差异（P〉0.05）。结论前列地尔脂微球制剂能有效地防止断指再植术后血管危象的发生,提高再植指体的成活率。

OBJECTIVE To investigate the clinical effect of Alprostadil in prevention of vascular crisis after replantation of amputated fingers. METHODS A total of 60 cases with replantation of amputated fingers from January to March in 2014 in the hospital were divided into experimental group and control group randomly. Besides basic treatment for all cases,Papaverine and Alprostadil were used in experimental group while Papaverine and Heparin were used in the control group,and during one week after the surgery,occurrence of vascular crisis,capillary reaction,completely survival rate of replanted fingers were observed.RESULTS There were 29 survival cases in the experimental group,and necrosis only happened in 1 case,therefore the survival rate was 96.7%. In the control group,there were 28 cases survived,and necrosis happened in 2 cases,therefore the survival rate was 93.3%. There was no significant difference between the 2 groups（ P0.05）. CONCLUSION Alprostadil of lipid microsphere preparation can effectively prevent the occurrence of vascular crisis after replantation of amputated fingers and improve the survival rate of replanted fingers.