胃癌前病变与幽门螺杆菌的关系

The Relationship between Gastric Precancerous Lesions and Helicobacter Pylori

胃黏膜肠上皮化生和上皮内瘤变是公认的胃癌前病变,代表肿瘤性生长的起始阶段。幽门螺杆菌感染加重胃黏膜炎症,促进胃黏膜萎缩、肠上皮化生、上皮内瘤变,在胃癌的起始阶段,也就是胃癌前病变的发生和进展中起重要的作用。这一过程涉及幽门螺杆菌毒力因子、癌基因与抑癌基因等等,根除幽门螺杆菌治疗可能改善肠上皮化生和上皮内瘤变,降低无癌前病变患者的胃癌发生率。

Intestinal metaplasia of gastric mucosa and intraepithelial neoplasia are well recognized as the precancerous lesion of gastric cancer, which represents the starting stage of tumor growth. Helicobacter pylori infection leads to gastric mucosal inflammation, promotes gastric mucosal atrophy, intestinal metaplasia, intraepithelial neopiasia, in the initial stage of gastric cancer, and it plays an important role in the occurrence and progression of gastric cancer. This process involves Helicobacter pylori virulence factors, oncogenes and tumor suppressor genes, and the eradication of Helicobacter pylori may improve the intestinal metaplasia and intraepithelial neoplasia, and reduce the incidence of gastric cancer in patients without precancerous lesions.