阿奇霉素不同疗程治疗小儿肺炎支原体肺炎的疗效比较

Comparison of the clinical efficacy of azithromycin in the different course treatment of children with myco- plasma pneumonia

目的：探讨阿奇霉素不同疗程治疗小儿肺炎支原体肺炎的临床疗效。方法选择120例 MPP治疗的患儿，按照治疗方案分为两组，在常规治疗的同时给予不同疗程的阿奇霉素进行治疗，治疗1组42例为单次疗程3 d，治疗2组78例为单次疗程超过3 d，治疗2组按照单次疗程超过3 d，其中又分为2组 A 22例、2组 B 41例、2组 C 15例三组，单次疗程分别为5 d、7 d、8 d，观察患儿体温恢复正常的时间，以及咳嗽、肺部啰音消失的时间，住院的时间。结果治疗2组的发热时间、啰音消失时间均低于治疗1组，但差异均无统计学意义[（2．99±2．84）d 比（3．24±3．03）d，（6．57±4．33）d 比（6．84±4．67）d，t ＝0．4493、0．3169，均P ＞0．05]。治疗2组的咳喘时间和住院时间均低于治疗1组，差异均有统计学意义[（8．32±4．16）d 比（10．21±5．16）d，（9．52±3．67）d 比（13．33±6．77）d，t ＝2．1787、4．0044，均 P ＜0．05]。A、B、C 三组的发热时间差异均无统计学意义（均 P ＞0．05），B 组的咳喘时间、啰音消失时间以及住院时间较 A、C 两组显少，差异均有统计学意义（均 P ＜0．05），但 A 组与 C 组差异均无统计学意义（均 P ＞0．05）。结论应用阿奇霉素不同疗程治疗小儿肺炎支原体肺炎中，各个疗程对患儿退热的疗效无明显差异，但是对于患儿咳嗽、肺部啰音等临床症状，7 d 作为1个疗程是疗效最佳的。

Objective To explore the clinical efficacy of azithromycin in the different course treatment of children with mycoplasma pneumonia.Methods 1 20 children with mycoplasma pneumonia were divided into two groups according to the treatment plan.Adding different treatment course azithromycin treatment based on conventional treatment,treatment group 1 （42cases）for a single course of 3 days,the treatment group 2 （78cases）single course more than 3d,treatment group 2 including group 2 -A （22cases）and group 2 -B （41 cases）and group 2 -C （1 5cases）,the single course of treatment,respectively,5d,7d,8d.Patients＆#39;body temperature returned to normal time, and the disappearing time of cough,lung rale and the time in the hospital were observed.Results The fever and lung rale disappearing time of the treatment 2 group were lower than those of treatment 1 group,while there were no signifi-cant differences[（2.99 ±2.84）d vs.（3.24 ±3.03）d,（6.57 ±4.33）d vs.（6.84 ±4.67）d,t =0.449 3,0.31 6 9, all P 〉0.05 ].The hospitalization time and cough time of treatment 2 group were lower than those of treatment 1 group,the differences were statistically significant[（8.32 ±4.1 6）d vs.（1 0.21 ±5.1 6）d,（9.52 ±3.67）d vs. （1 3.33 ±6.77）d,t =2.1 78 7,4.004 4,all P 〈0.05].The fever disappearing time of the A,B and C groups had no statistical differences（all P 〉0.05）,while the cough time,lung rale disappearing time and hospitalization time of B group were obviously lower than A and C group,the differences were statistically significant（all P 〈0.05）,there were no statistically significant differences between treatment A group and treatment C group（all P 〉0.05）.Conclusion Azithromycin in the different course treatment of children with mycoplasma pneumonia has no obvious difference for fever disappearing time.However,for the clinical symptoms such as cough and lung rale selecting 7 days as a course of treatment is the best.