摘要
目的:探讨白细胞介素-6在非霍奇金淋巴瘤中的表达及临床意义。方法收集107例初发非霍奇金淋巴瘤患者及50例健康体健者的血清标本,使用化学发光免疫分析法检测血清标本中白细胞介素-6的水平差异。结果侵袭性淋巴瘤组血清白细胞介素-6水平[(18.54±4.53)ng/L]明显高于惰性淋巴瘤组[(6.90±1.78)ng/L],并且两组血清白细胞介素-6水平均明显高于健康对照组[(3.87±0.76)ng/L];具有 B症状、骨髓浸润的淋巴瘤患者血清白细胞介素-6水平显著升高;淋巴瘤国际预后指数(IPI)高危组血清白细胞介素-6水平明显高于中危组及低危组;非霍奇金淋巴瘤患者血清白细胞介素-6水平与 IPI 或滤泡性淋巴瘤国际预后指数(FLIPI)评分、Ann Arbor 分期、B 症状及骨髓浸润呈显著正相关;通过对侵袭性淋巴瘤组患者疗效分析发现,完全缓解组患者血清白细胞介素-6水平显著高于非完全缓解组;通过二元 Logistic 回归分析发现,白细胞介素-6是影响非霍奇金淋巴瘤治疗效果的独立危险因素之一(P <0.05)。结论非霍奇金淋巴瘤患者血清中白细胞介素-6水平明显高于健康人群,且与肿瘤侵袭性、预后及疗效相关,可作为诊断及判断预后的辅助指标。
Objective To investigate the expression and clinical significance of interleukin -6 (IL -6)in aggressive and indolent lymphoma patients.Methods Serum specimens obtained from 1 07 non -Hodgkin's lympho-ma (NHL)patients and 50 healthy controls were collected.Chemiluminescence immunoassay was used to assess the expression of IL -6 in the serum.Results The level of serum IL -6(1 8.54 ±4.53)ng/L in aggressive lymphoma group was significantly higher than (6.90 ±1 .78)ng/L in the inert lymphoma group,and the serum IL -6 levels of two groups were significantly higher than the healthy control group (3.87 ±0.76)ng/L.The lymphoma patients,with B symptoms,elevated CRP or bone marrow involvement presented higher IL -6 level than the other patients (P 〈0.05).IL -6 level of the IPI high -risk group was higher than the intermediate -risk group and low -risk group, with significant difference (P 〈0.05 ).The correlation study showed that IL -6 and CRP,IPI /FLIPI,Ann Arbor stage,B symptoms,bone marrow involvement had significantly positive correlation (P 〈0.05);Through analysis of the effect of the patients with aggressive lymphoma,the serum level of IL -6 in patients with complete remission was sig-nificantly higher than the non complete remission group.By Logistic regression analysis,IL -6 was one of the inde-pendent risk factors affecting the treatment effect of NHL,and the difference was statistically significant (P 〈0.05). Conclusion The serum IL -6 was significantly elevated in NHL patients,in association with tumor invasion,progno-sis and therapeutic effect.IL -6 may help the diagnosis and prognosis of NHL.
出处
《中国基层医药》
CAS
2015年第24期3783-3786,共4页
Chinese Journal of Primary Medicine and Pharmacy