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非霍奇金淋巴瘤中白细胞介素-6的表达及其临床意义 被引量:1

The expression and clinical significance of interleukin -6 in non -Hodgkin's lymphoma
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摘要 目的:探讨白细胞介素-6在非霍奇金淋巴瘤中的表达及临床意义。方法收集107例初发非霍奇金淋巴瘤患者及50例健康体健者的血清标本,使用化学发光免疫分析法检测血清标本中白细胞介素-6的水平差异。结果侵袭性淋巴瘤组血清白细胞介素-6水平[(18.54±4.53)ng/L]明显高于惰性淋巴瘤组[(6.90±1.78)ng/L],并且两组血清白细胞介素-6水平均明显高于健康对照组[(3.87±0.76)ng/L];具有 B症状、骨髓浸润的淋巴瘤患者血清白细胞介素-6水平显著升高;淋巴瘤国际预后指数(IPI)高危组血清白细胞介素-6水平明显高于中危组及低危组;非霍奇金淋巴瘤患者血清白细胞介素-6水平与 IPI 或滤泡性淋巴瘤国际预后指数(FLIPI)评分、Ann Arbor 分期、B 症状及骨髓浸润呈显著正相关;通过对侵袭性淋巴瘤组患者疗效分析发现,完全缓解组患者血清白细胞介素-6水平显著高于非完全缓解组;通过二元 Logistic 回归分析发现,白细胞介素-6是影响非霍奇金淋巴瘤治疗效果的独立危险因素之一(P <0.05)。结论非霍奇金淋巴瘤患者血清中白细胞介素-6水平明显高于健康人群,且与肿瘤侵袭性、预后及疗效相关,可作为诊断及判断预后的辅助指标。 Objective To investigate the expression and clinical significance of interleukin -6 (IL -6)in aggressive and indolent lymphoma patients.Methods Serum specimens obtained from 1 07 non -Hodgkin's lympho-ma (NHL)patients and 50 healthy controls were collected.Chemiluminescence immunoassay was used to assess the expression of IL -6 in the serum.Results The level of serum IL -6(1 8.54 ±4.53)ng/L in aggressive lymphoma group was significantly higher than (6.90 ±1 .78)ng/L in the inert lymphoma group,and the serum IL -6 levels of two groups were significantly higher than the healthy control group (3.87 ±0.76)ng/L.The lymphoma patients,with B symptoms,elevated CRP or bone marrow involvement presented higher IL -6 level than the other patients (P 〈0.05).IL -6 level of the IPI high -risk group was higher than the intermediate -risk group and low -risk group, with significant difference (P 〈0.05 ).The correlation study showed that IL -6 and CRP,IPI /FLIPI,Ann Arbor stage,B symptoms,bone marrow involvement had significantly positive correlation (P 〈0.05);Through analysis of the effect of the patients with aggressive lymphoma,the serum level of IL -6 in patients with complete remission was sig-nificantly higher than the non complete remission group.By Logistic regression analysis,IL -6 was one of the inde-pendent risk factors affecting the treatment effect of NHL,and the difference was statistically significant (P 〈0.05). Conclusion The serum IL -6 was significantly elevated in NHL patients,in association with tumor invasion,progno-sis and therapeutic effect.IL -6 may help the diagnosis and prognosis of NHL.
出处 《中国基层医药》 CAS 2015年第24期3783-3786,共4页 Chinese Journal of Primary Medicine and Pharmacy
关键词 淋巴瘤 非霍奇金 淋巴瘤 弥漫性 淋巴瘤 滤泡性 白细胞介素 6 Lymphoma,non -Hodgkin Lymphoma,diffuse Lymphoma,follicular Interleukin -6
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参考文献22

  • 1Renatc Burger. Impact of intedeukin-6 in hematological malignan- Cies[ J]. Transfus Med Hemother,2013,40 (5) :336-343.
  • 2Yasukawa K,Hirano T, Watanabe Y ,et al. Structure and expres- sion of human B cell stimulatory factor-2 (BSF-2/IL-6) gene [J]. EMBO, 1987,6(10) :2939-2945.
  • 3Hong DS, Angelo LS, Kurzrock R. Interleukin-6 and its receptor in cancer :implications for translational therapeutics~ 3 ]. Cancer, 2007,110 (9) : 1911-1928.
  • 4Mihara M, Hashizume M, Yoshida H, et al. IL-6/IL-6 receptor system and its role in physiological and pathological conditions [J]. Clin Sci(Lond) ,2012,122(4) :143-159.
  • 5Losses IS, Morgensztem D. Prognostic biomarkers in diffuse large B-cell lymphoma[ J ]. Clin Oneol,2006,24 (6) :995-1007.
  • 6Kurzreck R. Cytokine deregulatian in cancer[ J]. Biomed Phanna- cother,2001,55 (9-10) :543-547.
  • 7Salles G, Coffier B. Inherited eytokine response and risk of lym- phoma[ J]. Lancet Oneol,2006,7(2) :3-4.
  • 8Van Snick J. Interleukin-6 :an overview[ J ]. Annu Rev hnraunol, 1990,8:253-257.
  • 9Xirouchaki N, Tzanakis N, Boures D, et al. Diagnostic value of in- terleukin-I ,interleukin-6, and tumor necrosis factor in pleural ef- fusions[ J]. Chest,2002,121 (3) :815-820.
  • 10Niwa T, Niyazaki T, Satom M, et al. Interleukin-8 and biocompati- bility of dialysis membranes [ J]. Am J Nephrol, 2005,15 ( 3 ) : 181-185.

二级参考文献15

  • 1Elfar M, Fouda M, Yahya R, et al. Serum IL-10 and IL-6 levels at diagnosis as independent predictors of outcome in non-Hodgkin's lymphoma[J]. J Physiol Biochem, 2004, 60(4): 253-8.
  • 2Nacinovic-duletic A, Stifter S, Dvomik S, et al. Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in. patients with diffuse large B-cell lymphoma[J]. Int Jnl Lab Hem, 2008, 30(2): 230-9.
  • 3Sana I, Christine M, Sylvie C, et al. Serum cytokines in follicular lymphoma. Correlation of TGF-β and VEGF with survival[J]. Ann Hematol, 2010, 89(1): 25-33.
  • 4Jaffy ES, Harris NL, Stein H, et al. World health organization classification of tumours pathology and genetics of tumours of haematopoietic and lymphoid tissues [M]. 4th Lyon: IARC Press: 2008:158-334.
  • 5Casasnovas R, Mounier N, Bric P, et al. Plasma Cytokine and Soluble Receptor Signature Predicts Outcome of Patients With Classical Hodgkin's Lymphoma: A Study From the Oroupe d'Etude des Lymphomes de l'Adulte[J]. Clin Oncol, 2007, 25(30): 1732-41.
  • 6Pedersen LM, Klausen TW, Davidsen UH, et al. Early changes in serum IL-6 and VEGF levels predict clinical outcome following first-line therapy in aggressive non-Hodgkin' s lymphoma [J]. Ann Hematol, 2005, 84(11): 510-6.
  • 7Stefan H, Manuela G, Giuseppina M, et al. Clinical significance of Interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma[J]. Leukemia Res, 2009, 33(23): 1352-56.
  • 8Ewa B, Anna B, Elzbieta A, interleukin- 10, interleukin-12 therapy and probability of et al. Pre-treatment serum levels of and their ratio predict response to event-free and overall survival in childhood soft tissue sarcomas, Hodgkin's lymphomas and acute lymphoblastic leukemias[J]. Clin Biochem, 2009, 42(32): 1144-57.
  • 9Aydin F, Yilmaz M, Ozdemir F, et al. Correlation of serum IL-2, IL-6 and IL-10 levels with International prognostic index in patients with aggressive non-Hodgkin' s lymphoma [J]. Am Clin Onco, 2002, 25(4): 570-2.
  • 10Lech-Maranda E, Baseggio L, Bienvenu J, et al. Interleukin-10 gene promoter polymorphisms influence the clinical outcome of diffuse large B-cell lymphoma [J]. Blood, 2004, 103(41): 3529-34.

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