干细胞移植对缺血性脑卒中患者血清同型半胱氨酸、CRP及BDNF含量影响研究

Effect of stem cell transplantation on serum homocysteine,CRP and BDNF in patients with ischemic stroke

目的探讨干细胞移植对缺血性脑卒中患者血清同型半胱氨酸(homocysteine,Hcy)、C反应蛋白(C reactive protein,CRP)及脑源性神经生长因子(brain derived neurotrophic factor,BDNF)含量的影响。方法收集宜昌市第一人民医院收治的缺血性脑卒中患者42例,随机分为实验组和对照组,每组各21例,对照组给予常规治疗,实验组在常规治疗基础上给予自体骨髓间充质干细胞移植治疗,治疗结束后,对所有患者的血清Hcy、CRP、BDNF水平及临床疗效情况进行检测。结果治疗后,与对照组比较,实验组患者的血清Hcy水平较低,差异具有统计学意义(P<0.05);实验组患者的血清CRP水平较低(P<0.05);实验组患者的BDNF水平较高(P<0.05);实验组患者的实验组患者的FIM、ADL、Fugl-Meyer评分较高(P<0.05)。结论干细胞移植能够显著降低缺血性脑卒中患者血清Hcy、CRP水平,提高血清BDNF含量,提高治疗效果。

Objective To analysis the effect of stem cell transplantation on serum homocysteine（ Hcy）,C reactive protein（ CRP） and brain derived neurotrophic factor（ BDNF） in patients with ischemic stroke. Methods 42 patients who were diagnosed with ischemic stroke in Yichang First People＇s Hospital were collected. All patients were randomly divided into experimental group and control group,21 cases in each group. The control group was treated with conventional therapy,and the experimental group was treated with autologous bone marrow mesenchymal stem cell transplantation for treatment on the basis of conventional therapy,after treatment,the serum levels of serum homocysteine,CRP,BDNF and clinical curative effect were detected in all patients. Results After treatment,compared with control group,the serum Hcy level was lower in the experimental group（ P〈0. 05）; the serum CRP level was lower in the experimental group（ P〈0. 05）; the serum BDNF level was higher in the experimental group（ P〈0. 05）; the FIM,ADL and Fugl-Meyer score were higher in the experimental group（ P〈0. 05）. Conclusions The stem cell transplantation can significantly reduce the serum Hcy and CRP levels in patients with ischemic stroke,increase the content of BDNF in serum,improve the therapeutic effect,and have a guiding significance for clinical.