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外周血NLR与PLR对原发性胃癌患者生存状况的评估价值 被引量：8

Value of peripheral NLR and PLR for the survival of patients with primary gastric cancer
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摘要 目的探讨原发性胃癌患者入院时中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)和血小板与淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)对胃癌患者生存预后的预测价值。方法分析132例原发性胃癌患者及30例健康对照的临床资料,采用Kaplan-Meier、Log-rank检验、多元COX回归分析胃癌患者的生存状况。结果病例组NLR、PLR水平均明显高于健康对照组(t=6.67,P=0.000;t=13.23,P=0.000);年龄越高、肿瘤直径越大、临床分期越高、分化程度越差、出现淋巴结转移及未进行手术治疗NLR、PLR有升高的趋势(P<0.05);NLR与PLR呈明显的正相关关系(r=0.3164,P=0.0002);低NLR组生存时间为(57.59±2.23)月(中位生存时间为55个月),高NLR组生存时间为(35.22±3.09)月(中位生存时间为37个月),2者差异有统计学意义(χ2=6.298,P=0.0361);低PLR组生存时间为(54.09±2.66)月(中位生存时间为54个月),高PLR组生存时间为(35.22±2.75)月(中位生存时间为37个月),2者差异有统计学意义(χ2=5.879,P=0.0377)。胃癌患者总体生存期的独立影响因素有年龄、临床分期、有无淋巴结转移及NLR、PLR水平(P<0.05)。结论胃癌患者NLR、PLR显著升高,与患者的年龄、肿瘤大小、转移程度、临床分期等密切相关,并且对于患者的生存预后变差具有一定的预测价值。 Objective To investigate value of peripheral NLR and PLR for the survival of patients with primary gastric cancer. Methods The clinical data of 132 primary gastric cancer patients and 30 healthy controls were analyzed by the Kaplan-Meier,Log-rank test and multivariate COX regression. Results NLR,PLR levels of the case group were significantly higher than that in the healthy control group（ t = 6. 67,P = 0. 000; t = 13. 23,P = 0. 000）; the higher the age,the greater tumor diameter,the higher the degree of differentiation,lymph node metastasis,and not be treated with surgery,NLR and PLR could increase（ P〈0. 05）; NLR and PLR showed a significant positive correlation（ r = 0. 3164,P = 0. 0002）; survival time of low NLR group was（ 57. 59 ± 2. 23） months and high NLR group was（ 35. 22 ± 3. 09） months（ P〈0. 05）; survival time of low PLR group was（ 54. 09± 2. 66） months and high PLR group was（ 35. 22 ± 2. 75） months（ P〈0. 05）; age,clinical stage,lymph node metastasis and NLR,PLR levels were independent factors for the overall survival in patients with gastric cancer（ P〈0. 05）. Conclusion NLR and PLR of gastric cancer patients increase significantly and are closely related to tumor size,metastasis,clinical stage,and the deterioration,which showes some predictive value for the survival prognosis of the patients.
作者 陈志奇 刘朔婕 陈波
机构地区 厦门大学附属第一医院检验科
出处 《中国生化药物杂志》 CAS 2015年第9期103-105,108,共4页 Chinese Journal of Biochemical Pharmaceutics
关键词 原发性胃癌 中性粒细胞与淋巴细胞比值(NLR) 血小板与淋巴细胞比值(PLR) 生存预后 primary gastric cancer neutrophil and lymphocyte ratio（NLR） platelet and lymphocyte ratio（PLR） survival prognosis
分类号 R735.34 [医药卫生—肿瘤]
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参考文献11

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中国生化药物杂志
2015年 第9期

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