三联疗法与序贯疗法在长期服用拜阿司匹林者根除幽门螺杆菌的疗效观察

Effect of triple therapy and sequential therapy on eradication of Helicobacter pylori in long-term aspirin use

目的探讨三联疗法与序贯疗法在长期服用拜阿司匹林者根除幽门螺杆菌的疗效。方法收集收治的长期服用拜阿司匹林的幽门螺旋杆菌感染患者52例,根据用药不同分为三联组和序贯组,每组各26例,分别给予相应的药物治疗,治疗结束后,对所有患者的血清胃蛋白酶原含量、Hp-Ig G抗体水平及幽门螺旋杆菌清除率进行检测。结果治疗后,与三联组比较,序贯组患者血清PGⅠ、PGⅡ含量较低,PGⅠ/PGⅡ较高,差异具有统计学意义(P<0.05);序贯组患者的血清Hp-Ig G抗体水平较低(P<0.05);序贯组患者的Hp清除率较高(P<0.05)。结论与三联疗法相比,序贯疗法能够更好的降低血清PGⅠ、PGⅡ以及Hp-Ig G水平,提高Hp清除率,对临床有指导意义。

Objective To analysis curative effect of triple therapy and sequential therapy for eradication of Helicobacter pylori in patients with long-term aspirin use. Methods 52 patients with long-term aspirin use who were diagnosed with helicobacter pylori infection were collected. All patients were divided into sequential group and triple group according to different drugs classified,each 26 cases in each group were given corresponding drug treatment,after the end of treatment,the serum pepsinogen,Hp-Ig G antibody levels and Helicobacter pylori clearance rate were detected in all patients.Results After treatment,compared with the triple Group,in the sequential group,the levels of serum PG I and PG II were lower,and PGⅠ / PGⅡwas higher,and the differences were statistically significant（ P〈0. 05）; the serum Hp-Ig G antibody levels were lower in the sequential group（ P〈0. 05）;the Hp clearance rate of patients in the sequential group was higher（ P〈0. 05）. Conclusion Compared with triple therapy,sequential therapy can lower serum PG,PG II and Hp-Ig G levels,and improve the Hp clearance rate and clinical efficacy,have guiding significance to clinical.