β-七叶皂甙钠对急性脑梗死患者血管内皮功能、同型半胱氨酸、超敏C反应蛋白及临床疗效的影响研究

Study on effect of β-Sodium aescinate on vascular endothelial function,homocysteine,hypersensitive C-reactive protein and clinical efficacy in patients with acute cerebral infarction

目的探讨β-七叶皂甙钠对急性脑梗死患者血管内皮功能、同型半胱氨酸及超敏C反应蛋白及临床疗效的影响。方法将保定市第二医院2013年3月-2015年4月收治的198例患者随机分为观察组（n=100）和对照组（n=98）。对照组根据病情给予对症治疗,治疗组在对照组的基础上给予β-七叶皂甙钠20 mg加入250 m L生理盐水进行静脉滴注,1次/天。连续使用14 d为1疗程。观察比较2组血管内皮功能（FMD）、同型半胱氨酸（Hcy）、超敏C反应蛋白（hs-CRP）的水平以及临床疗效的变化。结果观察组总有效率90.00%,明显高于对照组的71.42%,2组比较差异有统计学意义（χ2=11.01,P〈0.05）。治疗后观察组和对照组分别与治疗前相比,FMD显著升高,Hcy和hs-CRP均显著降低（P〈0.05）;但治疗后观察组与对照组相比,治疗组FMD显著高于对照组,Hcy和hs-CRP则显著低于对照组（P〈0.05）。结论β-七叶皂甙钠治疗急性脑梗死患者临床疗效显著,患者FMD显著升高,Hcy和hs-CRP显著降低。

Objective To explore β-sodium aescinate on vascular endothelial function（ FMD）,homocysteine（ Hcy） and hypersensitive Creactive protein（ hs-CRP） and clinical efficacy in patients with acute cerebral infarction. Methods 198 acute cerebral infarction patients from March2013 to April 2015 were randomly divided into observation group（ n = 100） and control group（ n = 98）. Control group were treated according to the condition of the disease,observation group were treated by β-sodium aescinate base on control group,20 mg was added to 250 m L saline for intravenous drip,one times per day. Continuous used 14 d for one treatment courses. Compared the change of vascular endothelial function,Hcy and hs-CRP and clinical efficacy. Results The total effective rate of observation group was 90. 00%,which was significantly higher than that of 71. 42% in control group（ χ2= 11. 01,P〈0. 05）. Post-treatment the value of FMD significantly increased,Hcy and hs CRP were significantly decreased both in observation group and control group respectively,which the difference had a statistically significant as compared with Pre-treatment（ P〈0. 05）; but,the value of FMD was significantly higher,Hcy and hs CRP was significantly lower in observation group than that of control group（ P〈0. 05）. Conclusion It has a significant β-sodium aescinate clinical effect in treatment of acute cerebral infarction,and FMD are significantly higher,Hcy and hs-CRP are significantly decrease.