心肌缺血再灌注损伤的中医药研究进展及其模型的制备

Research on Chinese medicine progress and model preparation of myocardial ischemia-reperfusion injury

缺血性心肌病(ischemic cardiomyopathy,ICM)是因冠状动脉粥样硬化导致长期心肌缺血,使心肌弥漫性纤维化,产生与原发性扩张型心肌病类似的临床综合征,是临床常见疾病之一,对人类健康的危害日益加重。及时恢复血液灌注使冠状动脉实现再通是有效的治疗方法之一。然而,组织和器官得到再灌注的同时又会带来新的损伤,这就是心肌缺血再灌注损伤。本文就目前心肌缺血再灌注损伤的中医药研究进展以及如何建立一个简便高效的实验动物模型来模拟人类心肌缺血再灌注损伤进行综述。

Ischemic cardiomyopathy（ ICM） is due to coronary atherosclerosis cause long-term myocardial ischemia,make myocardial fibrosis diffuse,produce similar clinical syndrome like idiopathic dilated cardiomyopathy,which is one of a common clinical disease and causes increasing hazards to human health. Timely recovery of blood perfusion and coronary artery recanalization is one of the effective methods of treatment. However,it brings new damage while tissues and organs receive reperfusion,which is myocardial ischemia-reperfusion injury. In this paper,the current research progress in medicine myocardial ischemia-reperfusion injury and how to build a simple and efficient experimental animal models to mimic human myocardial ischemia-reperfusion injury were reviewed.