应用小分子肝素钙对过敏性紫癜并发远期肾损害干预效果的Meta分析

Effect of appling small molecule heparin calcium on long-term renal damage of patients with allergic purpura by Meta analysis

目的应用Meta分析方法,评价小分子肝素钙对过敏性紫癜并发远期肾损害干预效果的。方法检索CNKI、万方、维普、CBM数据库及Cochrane图书馆,手工检索作为辅助,对纳入文献采取质量分析,采用Stata12.1软件行Meta分析。结果 4篇文献纳入随机对照临床试验(randomized controlled trials,RCT),样本共670例,其中333例小分子肝素钙治疗组(37例肾损害),337例对照组(44例肾损害),2组无明显差异(RR=0.89,95%CI:0.59-1.34,P=0.578)。结论早期应用小分子肝素钙可预防肾损害发生,但其远期干预效果并不明显,仍需通过多中心、大规模RCT做深入研究。

Objective To evaluate small molecule heparin allergic purpura complicated by long-term kidney damage intervention by Meta analysis.Methods Databases of CNKI,Wanfang,VIP,CBM and Cochrane Library were searched,hand searching as an auxiliary,included studies were assessed by quality of analysis,Meta-analysis was conducted by Stata12. 1 software line. Results 4 articles were included in randomized controlled clinical trials（ randomized controlled trials,RCT）,a sample of 670 cases,333 cases of small molecule heparin calcium treatment group（ 37 cases of renal damage has occurred）,337 cases of control group（ 44 cases of renal damage has occurred）,no difference between the 2 groups（ RR = 0. 89,95% CI： 0. 59-1. 34,P = 0. 578）. Conclusion The early application of small molecular weight heparin calcium can not prevent kidney damage,it needs to do in-depth research by multi-center,large-scale RCT.