加巴喷丁用于难治性慢性咳嗽治疗的研究进展

Progress of research on gabapentin for refractory chronic cough

综述加巴喷丁治疗难治性慢性咳嗽的研究进展,为其临床合理利用及进一步研究提供科学依据。检索中国知网、万方医学网、Pub Med近15年收载的公开发表的有关加巴喷丁治疗慢性咳嗽等感觉神经病变的研究文献并进行综述,对加巴喷丁的作用、机制及其安全性进行整理、归纳及分析。加巴喷丁用于治疗合并感觉神经障碍的难治性咳嗽有效、安全,具有新的临床应用价值,其有效治疗结果可能通过改善中枢敏感化而实现。但因其临床研究数量及资料较少,深入的作用机制及其长期应用的安全性有待进一步研究。

Objective To review advance of gabapentin in treatment of refractory chronic cough,and to provide evidence for its clinical usage and further study. The original articles referring to gabapentin＇s effect on sensory neuropathy such as refractory chronic cough,which were retrieved from CNKI,Wanfang Medical Network,as well as Pub Med over the last 15 years,were reviewed. The safety,efficacy and its mechanism of gabapentin were sorted,generalized and analyzed. Gabapentin appears to be effective and safe in the treatment of sensory neuropathic disorder such as refractory chronic cough,and its effective treatment results may come ture through improving central sensitization,which indicates the drug has new clinical application value. Relevant clinical trials investigating its efficacy and safety profile in the treatment of cough are limited and further research are needed.