黄芪对原发性肾小球肾炎患者血清白细胞介素-17和肿瘤坏死因子-α水平的影响

Effect of astragalus on the levels of serum interleukin-17 and tumor necrosis factor-α in patients with primary glomerulonephritis

目的观察黄芪对原发性肾小球肾炎(PGN)患者血清白细胞介素-17(IL-17)和肿瘤坏死因子-α(TNF-α)水平的影响。方法选择2012年1月至2015年3月在宝鸡市中医医院住院治疗的PGN患者68例,根据治疗方法分为黄芪治疗组和常规治疗组,每组34例。另选择同期体检健康者40例作为正常对照组。常规治疗组患者给予低蛋白饮食、低盐饮食、控制高血压、抗凝、预防感染等常规治疗措施;在常规治疗的基础上,黄芪治疗组患者给予黄芪注射液30 m L,加入50 g·L-1葡萄糖250 m L,静脉滴注,每日1次,14 d为1个疗程,治疗2个疗程。对2组患者血清IL-17、TNF-α水平及治疗效果进行比较。结果治疗前黄芪治疗组和常规治疗组患者血清IL-17、TNF-α水平比较差异无统计学意义(P>0.05),但显著高于正常对照组(P<0.05)。治疗后黄芪治疗组和常规治疗组患者血清IL-17、TNF-α水平显著低于治疗前(P<0.05)。治疗后黄芪治疗组患者血清IL-17、TNF-α水平显著低于常规治疗组(P<0.05)。常规治疗组和黄芪治疗组患者治疗总有效率分别为76.47%和91.18%;黄芪治疗组患者治疗总有效率显著高于常规治疗组(P<0.05)。结论黄芪可以降低PGN患者血清IL-17和TNF-α水平,减轻炎症反应,提高治疗效果。

Objective To study the effect of astragalus on the levels of serum interleukin-17（ IL-17） and tumor necrosis factor-α（ TNF-α） in patients with primary glomerulonephritis（ PGN）. Methods A total of 68 patients with PGN were selected in Baoji Hospital of Traditional Chinese Medicine from January 2012 to March 2015. The patients were divided into astragalus treatment group and routine treatment group according to the treatment method,34 patients in each group. A total of 40 healthy people were selected as normal control group. The patients in routine treatment group were treated with low protein diet,low salt diet,control hypertension,anticoagulation,prevention of infection and other conventional treatment measures. Based on the conventional treatment measures,the patients in astragalus treatment group were treated with astragalus injection 30 m L and 5% glucose injection 250 m L by intravenously guttae,once a day for two course of treatment,14 days was one course of treatment. The effect and the levels of serum IL-17,TNF-α were compared between the two groups. Results There was no significant difference in the levels of serum IL-17 and TNF-α between the two groups before treatment（ P〉0. 05）,but the levels of serum IL-17 and TNF-α in astragalus treatment group and routine treatment group were significantly higher than those in normal control group（ P〈0. 05）. The levels of serum IL-17 and TNF-α after treatment were significantly lower than those before treatment in astragalus treatment group and routine treatment group（ P〈0. 05）. The levels of serum IL-17 and TNF-α in astragalus treatment group were significantly lower than those in routine treatment group after treatment（ P〈0. 05）. The total effective rate in routine treatment group and astragalus treatment group was 76. 47% and 91. 18% respectively,the total effective rate in astragalus treatment group was significantly higher than that in routine treatment group（ P〈0. 05）. Conclusion Astragalus can reduce the levels of serum IL-17 and TNF-α,lessen the inflammatory reaction and improve the therapeutic effect in patients with PGN.