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雌激素受体在胃癌中的研究现状

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摘要 胃癌早期手术是根治其唯一的方法,然而大部分患者在确诊时就已失去了最佳的手术时机,因此预后往往很差。针对胃癌组织表达雌激素受体(ER),采用抗雌激素治疗或化疗辅助内分泌治疗,以抑制胃癌细胞的生长和发展可能是一条新的治疗途径。本文就ER及其各亚型结构、生物学功能及临床治疗与预后方面的进展作一综述。
作者 王震 陈于平
出处 《汕头大学医学院学报》 2015年第4期233-235,共3页 Journal of Shantou University Medical College
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参考文献22

  • 1PARKIN D M. International variation [J]. Oncogene, 2004, 23 (38) : 6329-6340.
  • 2TOKUNAGA A, KOJIMA N, ANDOH T, et al. Hormone receptors in gastric cancer [J]. European Journal of Cancer & CliniealOneology, 1983, 19(5): 687-689.
  • 3苏琦,敖启林,梁晓秋,周建国,李一琴.胃癌中ER与c-myc的相关性研究[J].中国肿瘤临床,2000,27(10):732-734. 被引量:12
  • 4ENMARK E, PELTO H M, GRANDIEN K, et al. Human estrogen receptor beta-gene structure , chromosomal localization, and expression pattern[J]. The Journal of Clinical Endocrinology and Metabolism, 1997, 82(12): 4258-4265.
  • 5WANG L, JIANG Z, SUI M, et al. The potential biomarkers in predicting pathologic response of breast cancer to three different chemotherapy regimens: a case control study[J].BMCCancer, 2009, 9: 226.
  • 6WANG Z, ZHANG X, SHEN P, et al. A variant of estrogen receptor-{alpha}, hER-{alpha}36: transductionofestrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (24) : 9063-9068.
  • 7SEILER T A, WALKER P, MARTINEZ E, et al. Identification of estrogen-responsive DNA sequences by transient expression experiments in a human breast cancer cell line[J]. Nucleic Acids Research, 1986, 14(22): 8755-8770.
  • 8周岩,张成武,窦拉加.ER、PR、PS2在胃癌组织中的表达及临床意义[J].青海医学院学报,2007,28(3):179-182. 被引量:2
  • 9XU C Y, LI J J, LU Y Y, et al. Estrogen receptor alpha and hedgehog signal pathway developmental biology of gastric adenocarcinoma[J]. Hepato Gastroenterology, 2012, 59(116) : 1319-1322.
  • 10PARK S H, CHEUNG L W, WONG A S, et al. Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha [J]. Molecular Endocrinology (Baltimore, Md), 2008, 22 (9) : 2085-2098.

二级参考文献22

  • 1谭端军,谷志远,汪鸿志,李卫东,刘志敏,王慧蓉.雌激素及其受体抑制剂在体外对人胃癌细胞增殖的影响[J].中华肿瘤杂志,1995,17(2):93-96. 被引量:20
  • 2徐景云,周岩冰.雌激素受体α和β及孕激素受体在胃癌中的表达及意义[J].山东医药,2006,46(5):47-48. 被引量:6
  • 3卢小梅,陈书媛,黄受方,张长淮.乳腺癌石蜡切片中显示雌、孕激素受体方法和阳性结果判断标准的探讨[J].中华病理学杂志,1996,25(6):329-331. 被引量:28
  • 4Kominea A,Konstantinopoulos PA,Kapranos N,et al.Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer[J].J Cancer Res Clin Oncol,2004,130(5):253-258.
  • 5Matsuyama S,Ohkura Y,Eguchi H,et al.Estrogen receptor beta is expressed in human stomach adenocarcinoma[J].J Cancer Res Clin Oncol,2002,128(6):319-324.
  • 6Woo IS,Park MJ,Choi SW,et al.Loss of estrogen receptor-alpha expression is associated with hypermethylation near its ATG start codon in gastric cancer cell lines[J].Oncol Rep,2004,11(3):617-622.
  • 7Wang M,Pan JY,Song GR,et al.Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma:correlation with prothymosin alpha and clinicopathological parameters[J].Eur J Surg Oncol,2007,33(2):195-201.
  • 8Sipponen P,Correa P.Delayed rise in incidence of gas-tric cancer in females results in unique sex ratio(M/F)pattern:etiologic hypothesis[J].Gastric Cancer,2002,5:213-219.
  • 9Wang M,Pan JY,Song GR,et al.Altered expressionof estrogen receptor alpha and beta in advanced gastricadenocarcinoma:Correlation with prothymosin alphaand clinicopathological parameters[J].Eur J Surg On-col,2007,33:195-201.
  • 10Chandanos E,Lindblad M,Rubio CA,et al.Tamox-ifen exposure in relation to gastric adenocarcinoma de-velopment[J].European Journal of Cancer,2008,44:1 007-1 014.

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