养血清脑颗粒联合西药治疗药源性头痛疗效观察

Observation on the Curative Effect of Yangxue Qingnao Granules combined with Western Medicine in the Treatment of Medication-overuse Headache

目的探讨养血清脑颗粒联合阿米替林治疗药物过度使用性头疼患者的疗效。方法选取我院于2013年8月—2015年1月收治的48例药物过度使用性头疼患者,每次口服养血清脑颗粒4 g,每日3次,饭前口服,连用4周后停药;同时予以每晚口服阿米替林25 mg,连用12周。记录治疗前后患者头痛发作频率、头痛持续时间、严重程度和治疗后药物不良反。结果养血清脑颗粒联合阿米替林治疗后,患者的头疼程度、头疼持续时间和头疼发作频率较治疗前明显改善(P<0.05);患者治疗后的不良反应发生率为8.4%,均为轻度不良反应。结论养血清脑颗粒联合阿米替林能有效缓解患者的头疼程度,缩短头疼持续时间,减少发作频率,具有良好的治疗效果,且安全性好,值得在临床上推广使用。

Objective To study the effect of Yangxue Qingnao granules combined with amitriptyline in the treatment of medieation-overuse headache. Methods 48 cases of patients with medication-overuse headache from August 2013 to January 2015 in our hospital were selected. They took orally Yangxue Qingnao granule 4 g each time, 3 times a day, administered before meal, and continued for 4 weeks. At the same time, they took orally amitriptyline 25 mg every night, and continued for 12 weeks. The headache attack frequency, headache duration, severity and adverse drug reactions before and after treatment were recorded. Results After the treatment of Yangxue Qingnao granules combined with amitriptyline, the headache attack frequency, headache duration and severity obviously improved （P〈0.05） . The adverse drug reaction was 8.4%, which was mild adverse reaction. Conclusion Yangxue Qingnao granules eombined with amitriptyline can effectively alleviate the patient＇s degree of headache, shorten the duration of headache, reduce seizure frequency, has good therapeutic effect and safety, and is worth popularizing in clinical application.