摘要
八聚体结合转录因子4(octamer-binding transcription factor 4,Oct4)属于POU转录因子家族,是维持胚胎干细胞自我更新及多能性的关键因子.其不仅表达于胚胎干细胞、原始生殖细胞以及胚胎性肿瘤细胞中,也在多种体细胞肿瘤中高表达,与恶性肿瘤的发生、发展密切相关.新近研究表明Oct4是Wnt及转化生长因子b信号通路的靶基因,参与维持结肠癌肿瘤干细胞的存活,对结肠癌的发生、复发、转移以及预后等有着深远的影响,本文将就Oct4与结肠癌发生、发展的关系作一综述.
Octamer-binding transcription factor 4（Oct4）,a member of the POU transcription factor family,is considered the key factor for maintaining self-renewal and pluripotency of embryonic stem cells.It is expressed not only in embryonic stem cells,germ cells and embryonic tumor cells but also in a variety of somatic cell tumors,and is closely related with the occurrence and development of malignant tumors.Recent studies have shown that Oct4 is the target gene of Wnt and transforming growth factor-β signaling pathways,and is involved in maintaining the survival of the colon cancer stem cells.The expression of Oct4 has a profound impact on the occurrence,recurrence,metastasis and prognosis of colorectal cancer.In this paper,we will review the relationship between Oct4 and colorectal cancer development and progression.
出处
《世界华人消化杂志》
CAS
2015年第33期5325-5332,共8页
World Chinese Journal of Digestology
基金
贵州省高层次人才科研条件特助基金资助项目
No.TZJF-2011-32~~
关键词
八聚体结合转录因子4
结肠癌
肿瘤干细胞
信号通路
预后
Octamer-binding transcription factor 4
Colorectal cancer
Cancer stem cells
Signaling pathways
Prognosis
