摘要
目的:探讨人类着色素干皮病基因(xeroderma pigmentosum group A,XPA)A23G多态性与食管癌易感性的关系.方法:计算机检索Pub Med、EMBASE、The Cochrane Library、Web of Science、中国生物医学数据库、万方数据库、中国期刊全文数据库、中文科技期刊数据库多个数据库,收集XPA基因A23G多态性与食管癌易感性的病例-对照研究.根据纳入与排除标准筛选符合标准的文献,提取数据并进行质量评价,采用STATA12.1统计软件进行Meta分析.结果:符合入选标准的9个病例-对照研究,其中实验组食管癌患者2065例,对照组非肿瘤患者3552例.Meta分析结果显示:XPA基因A23G位点多态性的等位基因模型、显性基因模型、隐性基因模型及相加基因模型与食管癌罹患风险无相关性,分别为:(OR=1.0 1,9 5%CI:0.7 6-1.3 4)、(OR=0.8 7,9 5%CI:0.6 1-1.2 3)、(OR=0.9 7,95%CI:0.66-1.42)、(O R=1.12,95%CI:0.65-1.92),但共显性基因模型与罹患食管癌的风险增高有统计学相关性(OR=1.20,95%CI:1.07-1.35).根据种族进行亚组分析显示:亚洲人群共显性基因模型与罹患食管癌的风险增高有统计学相关性(OR=1.25,95%CI:1.10-1.44),其余基因模型无统计学意义,高加索人群食管癌易感性与各遗传基因模型均无统计学意义(P>0.05).根据对照组纳入人群进行亚组分析显示:对照组来源人群的共显性基因模型与罹患食管癌的风险增高有统计学相关性(OR=1.26,95%CI:1.08-1.48),其余基因模型无统计学意义,对照组来源于医院的人群食管癌易感性与各遗传基因模型均无统计学意义(P>0.05).结论:XPA A23G基因多态性的等位基因、显性基因模型、隐性基因模型、相加基因模型与食管癌易感性可能无相关性,共显性基因模型与食管癌易感性可能有相关性.
AIM:To perform a Meta-analysis to evaluate the relationship between the A23 G polymorphism of the xeroderma pigmentosum group A(XPA) gene and susceptibility to esophageal cancer.METHODS:PubMed,EMBASE,The Cochrane Library,Web of Science,CNKI,CBM,Wanfang,and VIP were searched for case-control studies evaluating the relationship between the A23 G polymorphism of the XPA gene and susceptibility to esophageal cancer.Articles were assessed using pre-designed eligibility forms,according to the pre-defined eligibility criteria.Results were pooled using the STATA12.1 software to yield odds ratios(ORs) and 95%confidence intervals(CIs).RESULTS:A total of nine case-control studies involving 2065 esophageal cancer cases and3552 non-tumor controls were included.Meta-analysis suggested that susceptibility to esophageal cancer had no significant relationship with allele model(G vs A)(OR =1.01,95%CI:0.76-1.34),dominant model(GA+ AA vs GG)(OR = 0.87,95%CI:0.61-1.23),recessive model(AA vs GA + GG)(OR = 0.97,95%CI:0.66-1.42),or additive model(GG vs AA)(OR = 1.12,95%CI:0.65-1.92) of the XPA A23 G polymorphism,but was significantly associated with the codominant model(GA vs AA + GG)(OR = 1.20,95%CI:1.07-1.35).The result of subgroup analysis based on ethnicity and source of controls showed that in Asian populations and source controlled populations,the codominant model(GA vs AA+ GG) increased the risk of esophageal cancer(OR = 1.25,95%CI:1.10-1.44;OR = 1.26,95%CI:1.08-1.48).CONCLUSION:Susceptibility to esophageal cancer has no significant relationship with allele model,dominant model,recessive model or additive model of the XPA A23 G polymorphism,but significantly associates with the codominant model.
出处
《世界华人消化杂志》
CAS
2015年第33期5348-5355,共8页
World Chinese Journal of Digestology
关键词
XPA基因
单核苷酸多态性
食管癌
META分析
Xeroderma pigmentosum group A
Single nucleotide polymorphism
Esophageal cancer
Meta-analyses