嘉兴地区尖锐湿疣患者HPV基因分型分析

Analysis of HPV genotypes in patients with condyloma acuminatumin Jiaxing

目的：了解嘉兴地区尖锐湿疣患者人乳头瘤病毒（HPV）基因型感染情况及分布特点,为治疗提供一定的临床依据。方法：对2013年4月至2014年3月在我院皮肤科门诊就诊并查HPV分型的253例CA患者的临床资料进行回顾性分析,总结分布特征。结果：253例CA患者中222例检测出HPV阳性（89.16%）,共检测23种HPV亚型,发现20种阳性,其中43、44、83型未被检出。以HPV6、11型所占比例最高（79.73%）;HPV以单一型感染为主,共167例（75.23%）;55例存在2~6种亚型的混合感染（24.77%）,以高/低危型感染最多,共38例（69.09%）;CA患者患病高峰年龄为20~39岁年龄段（72.97%）。结论：嘉兴地区尖锐湿疣患者HPV以单一型为主,以低危型HPV6、11最常见,混合感染以高/低危型感染最多。

Objectives： To investigate the infection situation and distribution characteristics of human papiLlo- mavirus （HPV） genotypes in condyloma acuminatum （CA） patients in Jiaxing, to provide clinical evidence for its treat- ment. Methods： The infections subtypes and distribution characteristics of 253 CA patients treated in our hospital from April 2013 to March 2014 were analyzed. Results： 222 cases out of 253 were detected with HPV positive, including 23 HPV subtypes. I-IP~ -43, 44, 83 were not found. HPV6, 11 infection were the mainly infection type （79.73%）. There was 167 cases of single type of HPV with the rate of 75.23% ; 55 cases were detected with multiple infections （24.77%） and high/low risk type was mainly in multiple infections （69.09%）. Patients at the age of 20 -39 had higher infection rate of 72.97% （38 cases）. Conclusions： The infection of HPV in patients with CA in Jiaxing was mainly single type of HPV and low risk type of I-IPV （6/11）, and high/low risk type was mainly in multiple infections.