去氧孕烯炔雌醇片联合米非司酮对围绝经期功能性子宫出血患者子宫内膜的影响观察

Effect of desogestrel ethinylestradiol and mifepristone on theendometrial thickness of patients with perimenopausal dysfunctional uterine bleeding

目的:探究与分析去氧孕烯炔雌醇片及米非司酮对围绝经期功能性子宫出血患者子宫内膜厚度的影响因素、疗效及并发症观察结果。方法:选取我院自2012年11月至2014年11月收治的60例围绝经期功能性子宫出血患者作为研究对象,采取随机数字表法分为单药治疗组与联合治疗组,每组各30例。单药治疗组给予术后常规疗法,连续口服去氧孕烯炔雌醇片3个疗程,每个疗程持续一个月;联合治疗组在常规给予去氧孕烯炔雌醇片的同时,联合使用米非司酮,观察与比较两组患者治疗结束后体内激素水平变化(包括促性腺激素、卵泡刺激素、黄体生成素),子宫内膜厚度变化,以及对患者治疗结束后疗效和并发症的评估。结果:单药治疗组与联合治疗组的卵泡刺激素、黄体生成素、促性腺激素水平相比差异显著(t=3.98,P<0.05;t=4.58,P<0.05;t=4.21,P<0.05)。单药治疗组与联合治疗组子宫内膜厚度相比差异显著(χ2=5.68,P<0.05)。联合治疗组与单药治疗组临床疗效相比明显差异显著(χ2=5.67,P<0.05)。结论:去氧孕烯炔雌醇片联合米非司酮治疗围绝经期功能性子宫出血患者临床疗效突出,安全性较高,可作为一种理想方法应用于临床工作中。

Objectives： To explore and analyze the effect of desogestrel ethinylestradiol and mifepristone on the endometrial thickness of patients with perimenopausal dysfunctional uterine bleeding and its complications. Methods： 60 patients with perimenopausal dysfunctional uterine bleeding in our hospital from November 2012 to November 2014 were selected and randomly divided into mono -therapy group and combination therapy group, 30 cases in each group. Mono - therapy group received routine therapy postoperatively, i.e. continuous oral desogestrel ethinylestradiol for 3 courses of treatment, each course for a month. Combination therapy group was additionally giv- en mifepristone. Changes in hormone levels after treatment in beth groups including （ gonadotropins, follicle - stim- ulating hormone and luteinizing hormone） and endometrial thickness change were observed and compared. The treatment efficacy and complications were assessed. Results： Difference in the follicle - stimulating hormone, lute-inizing hormone and gonadotropin levels was significant between mono - therapy and combination therapy group （ t = 3.98, P 〈 0.05, t = 0.05, P 〈 0.05, t = 0. 05, P 〈 0. 05 ）. Difference in endometrial thickness between the two groups was significant （X2 = 5.68, P 〈 0. 05 ）. Difference in clinical curative effect between the two groups was significant （ X2 = 5.67, P 〈 0. 05）. Conclusions ： Desogestrel ethinylestradiol combined with mifepristone is effec- tive in treating patients with perimenopausal dysfunctional uterine bleeding. With high safety, it can be used as a kind of ideal treatment method in clinical.