美洛昔康用于紧急避孕的系统评价

Systematic review ofusing of meloxicam for emergency contraception

目的:探讨美洛昔康在紧急避孕中的应用及安全性。方法:依据统计学样本量进行分析,选取了2013年1月至12月符合要求的受试对象共144例,其中对照组72例,观察组72例,对照组采用安慰剂或阳性药物进行治疗,观察者采用美洛昔康进行治疗,治疗后对治疗情况进行系统评价。结果:组间比较及系统分析结果显示,使用美洛昔康后主导卵泡直径增大,排卵时间延长,其中美洛昔康30mg/d的避孕效果优于15mg/d。组间对比中两组不良反应发生率比较,差异无统计学意义(P<0.05)。结论:在紧急避孕过程中采用美洛昔康具有较好的效果且相对安全,但要合理选择用药剂量,从而减少临床不良反应,确保成功避孕。

Objectives： To investigate the application of meloxieam for emergency contraception and its safety. Methods： Based on the statistical sample size for analysis, 144 eases meeting the requirement from February 2013 to February 2014 were selected and divided into control group and observation group, each of 72 cases. The control group received placebo or positive drug for treatment, while observation group received meloxicam. The treatment efficacy was systematically evaluated. Results： After using meloxicam, the diameter of dominant follicle increased with extended period of ovulation, where the contraceptive effect of 30 mg/d meloxicam was better that that of the 15mg/d meloxicam. Difference in the incidence of adverse reactions between the two groups was not statistically significant （ P 〈 0. 05 ）. Condusions： In the course of emergency contraception, meloxicam is effective and safe, but the dose should be given reasonably to reduce clinical adverse reactions and ensure the success of con- traception.