骨质疏松性脊柱压缩骨折经皮椎体后突成形术后抗骨质疏松药物的疗效观察

Effect of anti-osteoporosis drugs in osteoporotic vertebral compression fractures

目的观察骨质疏松性脊柱压缩骨折经皮椎体后突成形术后应用抗骨质疏松药物的临床效果。方法117例骨质疏松性脊柱压缩骨折行经皮椎体后突成形术后患者根据术后联合应用不同抗骨质疏松药物分为A、B、C、D 4组,对比术后3、6、9、12个月各组疼痛视觉模拟评分法(Visual Analogue Scale,VAS)评分、骨密度、再发椎体骨折情况。结果 A、B、C、D组VAS评分均呈逐渐下降趋势,但较A组来说,D组下降幅度最大,C组次之,B组再次之(P<0.01)。A、B、C、D组骨密度均呈逐渐上升趋势,但较A组来说,D组上升幅度最大,C组次之,B组再次之(P<0.01)。术后6个月时A组出现2例、B组出现1例椎体骨折,C、D组未发生;术后10个月C组出现1例椎体骨折,其他组未出现。结论骨质疏松性脊柱压缩骨折术后联合应用抗骨质疏松药物可显著降低腰背部疼痛及椎体再骨折,增加骨质强度,因此,临床上术后应严格指导患者规律合理应用抗骨质疏松药物。

Objective To observe the clinical effect of anti-osteoporosis drugs in the treatment of osteoporotic vertebral compression fractures（OVCF）.Methods 117 patients with OVCF were randomly selected to four groups according to different anti-osteoporosis drugs（A,B,C and D）.After operation for 3,6,9,and 12 months,the patients in four groups were evaluated by Visual Analogue Scale（VAS）,bone mineral density,bone fractures.Results The scores of VAS in group A,B,C and D showed gradual decline trend.Compared with group A,the decline range of VAS scores in group D were the maximum,while those in group C were less than in group D and those in group B were less than in group C（P〈0.01）.The bone mineral density of group A,B,C and D showed gradual increase.Compared with group A,the increase range of VAS scores in group D were the maximum,while those in group C were less than in group D and those in the group B were less than in group C（P〈0.01）.In 6months after operation,group A had 2cases of vertebral fracture and group B had 1case,but C,D group did not happen.After operation for 10 months,group C had 1case of vertebral fracture,the other groups did not appear.ConclusionAnti-osteoporosis drugs significantly reduce low waist back pain,more vertebral fracture and enhance the bone strength in osteoporotic vertebral compression fractures,therefore,the clinical postoperative patients should reasonably apply anti-osteoporosis drug.