中药方剂对寻常型银屑病患者外周血Th17细胞相关细胞因子的影响

Chinese medicine formulae on Th17 related cytokines in peripheral blood in patients with psoriasis vulgaris

目的探讨自拟中药方对寻常型银屑病患者外周血Th17细胞相关细胞因子的影响。方法分析我科2013年4月—2015年4月收治的20例银屑病患者,采用自拟中药方治疗,检测治疗前后Th17细胞相关因子IL-17、IL-17F、IL-21、IL-22的表达水平。结果治疗后PBMC中IL-17、IL-17F、IL-21、IL-22的mRN表达水平明显低于治疗前,差异具有统计学意义(P<0.05)。结论 Th17细胞及相关因子与银屑病密切相关,采用自拟中药方治疗银屑病,可能通过抑制Th17细胞活化及下调IL-17、IL-17F、IL-21、IL-22 mRNA水平,而达到有效治疗的目的,临床检测IL-17、IL-17F、IL-21、IL-22 mRNA水平,或可作为银屑病进展和预后的免疫学指标。

Objective To explore the relation of self-made traditional Chinese medicine with Th17 related cytokines in the peripheral blood in patients with psoriasis vulgaris. Methods A total of 20 patients with psoriasis vulgaris who were admitted in our department from April,2013 to April,2015 were included in the study. The self-made traditional Chinese medicine was used for treatment. The expression levels of Th17 related cytokines,i. e. IL-17,IL-17 F,IL-21,IL-22,before and after treatment were detected. Results The mRNA expression levels of IL-17,IL-17 F,IL-21,and IL-22 in PBMC after treatment were significantly lower than those before treatment（ P〈0. 05）. Conclusion Th17 related cytokines are correlated with psoriasis vulgaris. Self-made traditional Chinese medicine can treat psoriasis vulgaris probably by inhibiting the activation of Th17 cells and down regulating mRNA levels of IL-17,IL-17 F,IL-21,and IL-22,so that the goal of effective treatment can be achieved. Clinical detection of mRNA levels of IL-17,IL-17 F,IL-21,and IL-22 can be served as the immunological indicators for the progression and prognosis of psoriasis vulgaris.