棘球蚴病防治成就及面临的挑战

Research Achievements and Challenges for Echinococcosis Control

棘球蚴病已成为影响全球公共卫生的重要传染病,我国为棘球蚴病高发区。在过去的半个多世纪,棘球蚴病的手术和药物治疗、基因组学研究、信号转导通路、棘球蚴对中间宿主肝脏增殖与损伤及疫苗研制方面均取得了长足进展,但在中间宿主的免疫诊断和药物治疗,以及终末宿主疫苗的研制方面仍然面临挑战。本文就棘球蚴病的防治在过去取得的成就和目前所面临的挑战作一综述。

Echinococcosis is an important communicable disease that has remarkable impacts on the global health. The disease is highly endemic in western China. In the last decades, achievements were obtained for the surgery and drug therapies for echinococcosis, as well as for studies on genomics, signaling pathways, and liver proliferation and injury of the intermediate hosts. Although steps have entered vaccine development, challenges remain in immunodiagnosis and drug treatment for intermediate hosts, and in vaccine development for definitive hosts. This paper gives an overview on the current achievements and challenges for echinococcosis control.