基于Plackett-Burman设计和Box-Behnken响应面法优化鼻鼽颗粒一步制粒工艺

Optimization of one-step pelletization technology of Biqiu granules by Plackett-Burman design and Box-Behnken response surface methodology

首先,以颗粒的合格率为指标,采用Plackett-Burman设计筛选鼻鼽颗粒一步制粒的显著性影响因素;在此基础上,以颗粒的合格率和含水量为指标,通过Box-Behenken设计对影响一步制粒工艺的显著性因素进行进一步优化,实验数据进行多元线性回归和二项式拟合,应用响应面法对最佳工艺进行预测分析。鼻鼽颗粒一步制粒的最佳工艺条件为:进风温度85℃,进样速度33 r·min-1,浸膏相对密度1.10。采用Plackett-Burman和Box-Behnken设计响应面法优化鼻鼽颗粒一步制粒的工艺预测性好,优选出的工艺稳定可靠,为鼻鼽颗粒产业化生产提供了可靠依据。

First with the qualified rate of granules as the evaluation index,significant influencing factors were firstly screened by Plackett-Burman design. Then,with the qualified rate and moisture content as the evaluation indexes,significant factors that affect one-step pelletization technology were further optimized by Box-Behnken design; experimental data were imitated by multiple regression and second-order polynomial equation; and response surface method was used for predictive analysis of optimal technology. The best conditions were as follows： inlet air temperature of 85 ℃,sample introduction speed of 33 r·min-1,density of concrete 1. 10. Onestep pelletization technology of Biqiu granules by Plackett-Burman design and Box-Behnken response surface methodology was stable and feasible with good predictability,which provided reliable basis for the industrialized production of Biqiu granules.