慢性肾脏病与甲状腺功能失调的相关性

Correlation of chronic kidney disease and thyroid dysfunction

目的探讨慢性肾脏病(CKD)患者的甲状腺功能状态。方法回顾性分析住院CKD患者1113例的临床资料,计算不同甲状腺疾病的患病率,比较不同CKD阶段甲状腺激素水平的差异。结果 CKD5和CKD1期患者的甲状腺功能减退(甲减)的患病率分别为10.3%和6.8%。伴随着肾小球滤过率(GFR)的下降,甲减的患病率增加。GFR与三碘甲状腺原氨酸总量呈正相关(r=0.415,P<0.05)。结论在CKD,尤其是CKD5期患者,甲减及正常甲状腺病态综合征患病率增高。CKD与甲状腺功能关系密切。

Objective To explore the status of thyroid function in the patients with chronic kidney disease （CKD）. Methods Clinical data of 1113 hospitaliZed patients with CKD were retrospectively analyzed. The prewdence of different kinds of thyroid diseases was calculated and the differences of thyroid hormone levels of patients in different stages of CKD were compared. Results The prevalence of hypothyroidism in the patients with CKD5 and CKD1 was 10. 3% and 6.8%, respectively. Hypothyroidism occurred more likely in CKD patients with decreased glomerular filtration rate（GFR）. GFR was positively correlated with total triiodothyronine（r=0. 415 ,P〈0. 05）. Conclusion There is a high prevahmce of hypothyroidism and euthyroid sick syndrome in the patients with CKD, especially at stage 5. CKD has a close relationship with thyroid function.