穴位局部分子靶点与艾灸作用机理

Molecular Target at Acupoint and Moxibustion Mechanism

穴位是接受针灸刺激的重要部位,穴位局部是接受刺激后出现应答响应的首要环节,从穴位局部分子靶点入手,是揭示艾灸作用机理研究的重要方向。目前,艾灸后穴位局部应答的整体分子事件、瞬时感受器电位通道家族分子、嘌呤信号分子、热休克蛋白家族分子、免疫相关分子的应答取得了一定研究进展,为回答艾灸作用原理提供了部分依据,也为未来继续深入研究提供了思考和借鉴。

Acupoint has been regarded as both crucial and initiate step for generating clinic efficacy by moxibustion therapy. So the molcular mechanism at local acupoint would to be an important target to uncover the mechanism of moxibustion.There are some progress has been made on gene expression profile, transient receptor potential, and purinergic signaling, heat shock protein, immu- nity-involved molecular at the moxibustioned site caused by moxibustion stimulation, which maybe provides some theoretical basis and some references for the future research.