穴位注射复方麝香注射液治疗急性脑梗死后真性延髓麻痹的临床观察

Observations on Effect of Acupoint Injection of Compound Musk Injection in Curing True Bulbar Paralysis after Acute Cerebral Infarction

目的:观察穴位注射复方麝香注射液治疗真性延髓麻痹的临床疗效,并观察对其预后产生重要作用的血栓素TXB2和前列环素6-keto-PGF1a的影响。方法:将60例真性延髓麻痹患者随机分为治疗组30例和对照组30例。治疗组采用穴位注射复方麝香注射液并配合基本药物治疗,对照组采用单纯基本药物治疗。观察2组治疗前后吞咽功能、言语功能及血浆TXB2和前列环素6-keto-PGF1a的变化。结果:治疗组吞咽功能的愈显率和总有效率分别为36.6%和86.6%,对照组分别为6.6%和56.6%,2组比较差异均有统计学意义(P<0.05)。治疗组言语功能的愈显率和总有效率分别为33.3%和73.3%,对照组分别为6.6%和50.0%,:2组比较差异均有统计学意义(P<0.05)。2组治疗后血浆TXB2和前列环素6-ketoPGF1a含量与同组治疗前比较,差异均具有统计学意义(P<0.01,P<0.05)。治疗组治疗后血浆TXB2和前列环素6-keto-PGF1a含量与对照组比较,差异均有统计学意义(P<0.05)。结论:穴位注射复方麝香注射液是一种治疗急性脑梗死后真性延髓麻痹的有效方式,能较大程度地提高患者吞咽功能和言语功能,并促进TXB2、6-keto-PGF1a的均衡。

Objective： To observe the clinical effect ofacupoint injection of compound muskinjection in curing true bulbar paral- ysis and its efficacy on Thromboxane （TXB2） and prostacyclin （6-keto-PGF1α） . Methods： 60 invalids with true bulbar paralysis were stochastically assigned to two different groups （a treatment group and a matched group）, each group containing 30subjects. The treatment group adoptedacupoint injection of compound musk injectionwithroutinemedicationand the matched group only adoptedroutine medication. Verbal function, function of deglutition and plasma TXB2 and 6-keto-PGF1αwere tested in the two groups before and after remedy. Results ： The cure and notable efficiencyand total efficiency for verbal functionwere36. 6% and86. 6% in the treatment group separately and 6. 6% and 56. 6% in the matched group separately ; The difference between the two groups was statistically vital （ P 〈 0. 05） . The cure and notable efficiency and total efficiencyfor function of deglutitiou were 33.3% and 73.3% in the treatment group separately and 6. 6% and 50. 0% in the matched group separately; The difference between the two groups was statistically vital （ P 〈0. 05 ） . There were statistically importantbefore-/after-treatment differences in plasma TXB2 and 6-keto-PGF1 αin the two groups （ P 〈 0.01, P 〈 0. 05） . There were statistically important after-treatment differences in plasma TXB2 and 6-keto-PGF1αbetween the treat- ment and matched groups （P 〈 0. 05 ） . Conclusion acupoint injection of compound musk injection is an valid way to help true bulbar paralysis after acute cerebral infarction. It can effectively improve verbal function, function of deglutition and regulate TXB2 and 6-ke- to-PGF1α in the invalids.