摘要
目的:探讨中效胰岛素联合薯蓣皂苷治疗老年2型糖尿病对于糖化血红蛋白的影响。方法:老年2型糖尿病患者160例根据随机抽签法分为治疗组与对照组各80例,2组都给予中效胰岛素治疗,在此基础上治疗组加用薯蓣皂苷治疗,都治疗4 w。结果:2组的胰岛素用量和血糖达标时间对比差异无统计学意义(P>0.05)。治疗后2组空腹血糖、餐后2 h血糖与糖化血红蛋白值都呈现明显下降的趋势(P<0.05),同时治疗后治疗组的空腹血糖、餐后2 h血糖与糖化血红蛋白值明显低于对照组(P<0.05)。治疗期间低血糖对照组发生率为10.0%,治疗组低血糖的发生率为8.8%,治疗组的低血糖发生率明显低于对照组(P<0.05)。结论:中效胰岛素联合薯蓣皂苷治疗老年2型糖尿病能有效降低血糖,安全性好,其作用可能通过降低糖化血红蛋白形成有关。
Objective: To investigate the glycated hemoglobin effects of intermediate-acting insulin combined diosgenin for trea- ting elderly patients with type 2 diabetes. Methods: 160 elderly patients with type 2 diabetes based on randomly were equally divided into treatment group and control group, both groups were given the intermediate-acting insulin therapy, on the basis of the treatment group were treated with diosgenin treatment for four weeks. Results: The blood glucose time and insulin dosage compared between the two groups were showed no significant difference (P 〉 0. 05) . After treatment, the fasting blood glucose, 2h postprandial glucose and glycosylated hemoglobin values were showed significant downward trend (P 〈 0.05 ), while the fasting blood glucose, 2h postprandial glucose and glycosylated hemoglobin values after treatment in the treatment group were significantly lower than the control group (P 〈 0. 05). During the treatment, the occurrence of hypoglycemia was 8.8% in the treatment group, so that was 10. 0% in the control group that the incidence of hypoglycemia in the treatment group was significantly lower than the control group ( P 〈 0. 05 ). Conclu- sion: The intermediate-acting insulin combined diosgenin for treating elderly patients with type 2 diabetes can reduce blood sugar, it has good security, which may by reducing glycated hemoglobin formation.
出处
《成都中医药大学学报》
2015年第4期59-61,71,共4页
Journal of Chengdu University of Traditional Chinese Medicine
关键词
中效胰岛素
糖尿病
薯蓣皂苷
老年人
糖化血红蛋白
Intermediate-acting insulin
diabetes
diosgenin
the elderly
glycated hemoglobin