3-氨基-4,4,4-三氟丁烯酸乙酯的清洁合成新技术

The New Technology On Clear Synthesis of Ethyl 3- amino- 4,4,4,- trifluorocronate

旨在优化3-氨基-4,4,4-三氟丁烯酸乙酯的合成,并寻找一条适用于工业化的工艺路线。以三氟乙酸、正丁醇、乙酸乙酯、硫酸铵等为原料,通过酯化、缩合、胺化反应一锅煮法合成了3-氨基-4,4,4-三氟丁烯酸乙酯。反应总收率为71%,产品质量分数为99.6%。该路线条件温和,操作简便,收率较高。

This article aims to obtain a reasonable route of ethyl 3 - amino - 4,4,4, - trifluorocronate on industrial scale. The target product was prepared by the one - pot method of esterification, condensation, ammoniation using trifluoroacetic acid, n - butanol, ethylacetate and ammonium sulfate as the raw materials. The total yield was 71%. The purity was 99. 6%. The route has advantages of mild conditions, simple opera- tion, easily available raw materials and high yield.