树参属化学成分与生物活性研究进展

Research Progress of Chemical Constituents and Pharmacological Activities of Genus Dendropanax

五加科树参属植物大多数为我国民间传统常用草药,药用历史悠久,具有祛风除湿、活血消肿的功效,被载录《中华本草》,《中药大辞典》,《全国中草药汇编》,《中国畲族医药学》等书籍中。系统查阅中国知网,万方,维普,Web of science,Sci Finder,Pubmed等国内外多个数据库,对树参属植物的化学成分与生物活性相关的内容进行了文献整理、分析及总结。结果表明,该属植物主要的化学成分为多炔类、苯丙素类、黄酮类、三萜类等化合物,具有抗炎、抗补体、抗肿瘤、杀虫、抗氧化等生物活性。此外,树参属与人参属亲缘关系密切,是具有潜在开发价值的药用植物群。然而,仅有树参Dendropanax dentiger,变叶树参D.proteus,乔木树参D.arboreus,黄漆木D.morbifera,三棱果树参D.trifidus和1个不确定种D.cf querceti进行了化学成分及生物活性研究,且与临床功效相关的研究较少。因此,亟需对树参属的化学成分及生物活性进行系统的研究,结合临床功效,阐明其药效物质基础及作用机制。本文从化学成分与生物活性两方面对国内外树参属植物研究概况进行了综述,以期为该属植物的质量控制、临床应用及合理开发提供重要的科学依据。

Most Dendropanax plants are used as traditional folk medicine and have functions of moisture and activating blood detumescence effects,which collected in Chinese Materia Medica,The Dictionary of Medicinal Plant,The National Assembly of Chinese Herbal Medicine,She-national Medicine,and others. Comprehensive analysis of the literatures on chemical constituents and pharmacological activities from genus Dendropanax,and they collected via piles of resources including CNKI,Wanfang,Weipu,Web of science,Sci Finder,Pubmed,and others. Polyacetylenes,phenylpropanoids,flavonoids and triterpenoids considered as the main constituents of Dendropanax. Both the extracts and monomeric compounds from Dendropanax possess anti-inflammatory,anticomplement,cytotoxic,insecticidal and antioxidant activities. Furthermore,Dendropanax and Panax are closely related,is a potential development value of medicinal plants. However, only has carried on the chemical constituents and pharmacological activities studies of Dendropanax dentiger, D. proteus, D. arboreus, D.morbifera,D. trifidus,and D. cf querceti,and with less clinical efficacy research. Therefore,has carried on the chemical constituents and pharmacological activities systematic studies of Dendropanax,combined with clinical efficacy,in order to clarify its material basis and mechanism. This review aims to provide comprehensive information on the phytochemistry and pharmacological research of Dendropanax based on scientific literatures. It will build up a new foundation for the quality control, clinal application, and resasonable development of Dendropanax plants.