2型糖尿病患者睡眠质量与血糖达标的相关性研究

Clinical study on the relationship between sleep quality and glycemic control in patients with type 2 diabetes mellitus

目的分析T2DM患者的睡眠质量对血糖控制达标的影响及相关因素。方法 T2DM患者205例,采用匹兹堡睡眠质量指数（PSQI）量表调查其睡眠质量。HbA_1c〈7%为血糖控制达标。以PSQI〉5分为睡眠障碍,将患者分为睡眠良好组55例和睡眠障碍组150例。结果 （1）T2DM患者伴发睡眠障碍的比例达73.2%（150/205）;（2）与睡眠良好组比较,睡眠障碍组血浆皮质醇、HbA_1c增高（t=-2.85、-3.87,P均〈0.05）,血糖达标率降低（χ^2=6.959,P〈0.05）。Logistic回归分析显示,睡眠障碍评分是血糖达标的影响因素（OR=3.735,P〈0.05）。结论睡眠障碍在T2DM患者中发生率高,可能是影响HbA_1c达标的因素之一。

Objective to investigate the effect of sleep quality on glycemic control in subjects with type 2 diabetic mellitus（T2DM）. Methods A total of 205 inpatients with T2DM were enrolled in this study.Each patient completed Pittsburg Sleep Quality Index（PSQI）questionnaire.The glycemic control target was HbA_1c〈7%.Patients were divided into two groups：non-sleep disorder group（n=55）,and sleep disorder group（n=150）defined as PSQI score 〉5points. Results The incidence of sleep disorder was 73.2%（150/205）among all the subjects.Plasma cortisol and HbA_1c in sleep disorder group were siginficantly higher（t=-2.85,-3.87,all P〈0.05）,whereas the rate of reaching glycemic control target was siginficantly lower（χ^2=6.959,P〈0.05）than those of non-sleep disorder group.Multiple logistic regression analysis showed that glycemic control target was positively correlated with PSQI scores（OR=3.74,P〈0.05）. Conclusion The high incidence of sleep disorder in patients with T2DM may be one of the risk factors affecting glycemic control.