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胰升血糖素样肽-1受体激动剂对血管内皮细胞保护作用的研究进展 被引量：4

Research progress of protective effect of GLP-1 receptor agonist on vascular endothelial cell
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摘要 T2DM患者常伴有高血糖、脂代谢异常、高血压、肥胖及IR等危险因素,从而导致血管内皮细胞功能障碍,增加心血管事件风险。胰升血糖素样肽-1(GLP-1)类似物及其受体激动剂,作为一种基于肠促胰素的治疗糖尿病新方法,其除了有效控制血糖外,对血管内皮细胞功能障碍也有改善作用。本研究概述了GLP-1类似物及其受体激动剂对血管内皮细胞的保护作用。 Type 2 diabetic patients often have risk factors such as hyperglycaemia,dyslipidaemia,hypertension,obesity and insulin resistance,which increase the risks of vascular endothelial dysfunction and cardiovascular events.GLP-1 analogue and its receptor agonist,is a novel therapy on diabetes targeting at incretin,which can effectively control blood glucose and improve vascular endothelial dysfunction.Here we summarize the protective effect of GLP-1 analogue and its receptor agonist on vascular endothelial cell.
作者 柯甦捷 薛耀明
机构地区 南方医科大学附属南方医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2015年第12期1127-1130,共4页 Chinese Journal of Diabetes
关键词 胰升糖素样肽-1 血管内皮细胞 糖尿病 2型 Glucagon-like peptide-1（GLP-1） Vascular endothelial cell Diabetes mellitus type 2
分类号 R587.1 [医药卫生—内分泌]
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中国糖尿病杂志
2015年 第12期

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