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13例血管免疫母细胞性T细胞淋巴瘤特征分析 被引量:1

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摘要 目的分析血管免疫母细胞性T细胞淋巴瘤(AITL)骨髓涂片(BMA)及流式细胞术(FCM)的检测结果,探讨其骨髓侵犯的诊断依据。方法回顾性分析13例AITL BMA及FCM检测结果,并与临床特征作比较分析。结果经BMA检测13例AITL患者中5例为不确定,骨髓中瘤细胞异形度低、比例低;FCM检测1例阳性、2例为不确定,免疫表型特征不突出。与阴性病例比较,阳性及不确定病例在临床特征、实验室特征以及骨髓继发性改变的例数均高于阴性组,包括发热及肝、脾淋巴结肿大;贫血、血小板减低以及白细胞计数的异常;骨髓增生程度的异常、浆细胞及嗜酸性细胞比例的增高。结论 BMA、FCM检测AITL骨髓侵犯的敏感性不高,涂片中异形细胞与临床表现、实验检测结果及骨髓继发改变相关,明确诊断需进行骨髓活检并结合临床与实验室其他指标综合判断。
作者 刘敏 井昶雯
出处 《临床检验杂志》 CAS CSCD 2015年第10期776-778,共3页 Chinese Journal of Clinical Laboratory Science
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参考文献9

  • 1勇威本,魏淑敏,庞玉滨,等.100例恶性淋巴瘤骨髓侵犯的观察[J].北京医学,1981,3(6):327—329.
  • 2Zeppa P, Marino G, Troncone G, et al. Fine-needle cytology andflow cytometry immunophenotyping and subclassification of non- Hodgkin lymphoma: a critical review of 307 cases with technical sug- gestions[ J]. Cancer, 2004, 102 ( 1 ) :55-65.
  • 3Cho YU, Chi HS, Park C J, et al. Distinct features ofangioimmuno- blastic T-cell lymphoma with bone marrow involvement [ J ]. Am J Clin Patho1,2009,131 ( 5 ) : 640-646.
  • 4Grogg KL, Morice WG, Macon WR. Spectrum of bone marrow find- ings in patientswith angioimmunoblastic T-cell lymphoma. Br J Haematol [ J ]. 2007,137 ( 5 ) :416 -422.
  • 5康愫意,孙剑笠,陶云霞,李晔雄,石远凯,孙燕,周立强.血管免疫母细胞性T细胞淋巴瘤25例临床特征及预后分析[J].疑难病杂志,2013,12(7):513-516. 被引量:5
  • 6Dupuis J, Boye K, Martin N, et al. Expression of CXCL13 by neo- plastic cells in angioimmunoblastic T-cell lymphoma (AITL) : a new diagnostic marker providing evidence that AITL derives from follicular helper T cells [ J ]. Am J Surg Pathol,2006,30 (4) :490-494.
  • 7Bal M, Gujral S, Gandhi Jet al. Angioimmunoblastic T-Cell lympho- ma: a critical analysis of clinical, morphologic and immunophenotypic features[J]. Indian J Pathol Microbiol, 2010,53 (4) :640-645.
  • 8Merchant SH, Amin MB, Viswanatha DS. Morphologic and immuno- phenotypic analysis of angioimmunoblastic T-cell lymphoma: Empha- sis on phenotypic aberrancies for early diagnosis [ J ]. Am J Clin Pathol, 2006 , 126( 1 ) :29-38.
  • 9. Chen W, Kesler MV, Karandikar N J, et al. Flow cytometric features of angioimmunoblastic T-cell lymphoma [ J 1. Cytometry Clin Cytom, 2006,70 (3) :142-148.

二级参考文献21

  • 1徐景勃,侯丽君,何志国,朱旬,陈璐华.CHOP方案治疗老年血管免疫母细胞性T细胞淋巴瘤10例分析[J].临床内科杂志,2005,22(2):135-135. 被引量:6
  • 2Vose J, Armitage J, Weisenburger D , et al. International peripheral T- cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes[J].J Clin Oncol,2008,26 ( 25 ) :4124-4130.
  • 3Vokurka S, Koza V, Vozobulovo V, et al. Angioimmunoblastic T-cell lymphoma as a very poor-prognosis malignancy-a single centre experience[J]. Klin Onkol,2012,25(3) :206-211.
  • 4Abouyabis AN, Shenoy PJ, Sinha R, et al. A systematic review and Meta-analysis of front-line anthracycline-based chemotherapy regimens for peripheral T-cell lymphoma [J]. ISRN Hematol, 2011 : 623924 .
  • 5Mourad N , Mounier N, Briere J, et al. Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d' Etude des lymphomes de I' Adulte (GELA) trials[J]. Blood, 2008,111(9) :4463-4470.
  • 6Delmer A, Fitoussi O, Gaulard P, et al. A phase II study of bortezomib in combination with intensied CHOP-like regimen ( ACVBP) in patients with previously untreated T-cell lymphoma: Results of the GELA LNH05-1 T trial[J]. J Clin Oncol ,2009 ,27 (15) :8554A.
  • 7Dogan A, Ngu LS, Ng SH, et al. Pathology and clinical features of angioimmunoblastic T-cell lymphoma after successful treatment with thalidomide[J]. Leukemia ,2005, 19( 5) :873-875.
  • 8Mori M, Inoue D, Arima H, et al. Therapeutic efficacy of cyclosporin A for refractory angiommunoblastic T celllymphoma[J] . Rinsho Ketsueku, 2010 ,51 (5) : 332-338.
  • 9Advani R, Horwitz S, Zelenetz A, et al. Angioimmunohlastic T cell lymphoma: Treatment experience with cyclosporine [J]. Leuk Lymphoma, 2007,48(3) :521-525.
  • 10Fabbri A, Cencini E, Pietrini A, et al. Impressive activity of lenalidomide monotherapy in refractory angioimmunohlastic T-cell lymphoma: report of a case with long-term follow-up [J]. Hematol Oneal, 2012, DOl: 10. 1002/hon. 2038.

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