期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

骨折愈合过程中VEGF的表达与调控及其作用的研究进展 被引量：17

Expression,regulation and the role of VEGF in fracture healing
原文传递
导出
摘要 血管内皮生长因子(vascular endothelial growth factor,VEGF)是介导血管生成的重要生长因子,对骨折愈合过程中血管生成有着重要的作用。国内外学者对VEGF在骨折愈合过程中的作用及其机制做了大量研究,本文对此进行归纳和总结。 VEGF is a key regulator of angiogenesis,and has an important effect on angiogenesis during fracture healing.Scholars worldwide have conducted a lot of researches on the role and mechanism of VEGF in fracture healing.The paper presents a summary of these researches.
作者 周正楠 张岩 邱旭升 施鸿飞 张子韬 陈一心
机构地区 南京中医药大学中西医结合鼓楼临床医学院 南京大学医学院附属南京鼓楼医院
出处 《中国矫形外科杂志》 CAS CSCD 北大核心 2015年第24期2248-2251,共4页 Orthopedic Journal of China
基金 国家自然科学基金资助项目(编号:81401795) 中央高校基本科研业务费资助项目(编号:20620140712) 南京市卫生局项目(编号:ZKX12016 YKK14076)
关键词 血管内皮生长因子 骨折 骨折愈合 VEGF fracture fracture healing
分类号 R683 [医药卫生—骨科学]
  • 相关文献

参考文献29

  • 1Morsel1 R, Einhorn TA. Emerging bone healing therapies[ J ]. J Or- thop Trauma,2010,24( 3 ) :4 - 8.
  • 2Roy H, Bhardwaj S, Yla - Herttuala S. Biology of vascular endothelial growth factors [ J ]. FEBS Lett,2006,580 ( 12 ) :2879 - 2887.
  • 3Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its re- ceptors [ J ]. Nat Med,2003,9 (6) :669 - 676.
  • 4Josko J, Gwozdz B, Jedrzejowska - Szypulka H, et al. Vascular endo- thelial growth factor (VEGF) and its effect on angiogenesis[ J]. Med Sci Monit,2000,6:1047 - 1052.
  • 5Bluteau G,Julien M,Magne D,et al. VEGF and VEGF receptors are differentially expressed in chondrocytes [ J ]. Bone, 2007,40 ( 3 ) : 568 - 576.
  • 6Wang DS, Yamazaki K, Nohtomi K, et al. Increase of vascular endo - thelial growth factor mRNA expression by 1,25 - dihydrexyvitaminD3 in human osteoblast - like cells [ J ]. J Bone Miner Res, 1996, 11 (4) :472 -479.
  • 7Kidd LJ, Stephens AS, Kuliwaba JS, et al. Temporal pattern of gene expression and histology of stress fracture healing[ J ]. Bone ,2010,46 (2) :369 -378.
  • 8杨庆秋,胡侦明,浦波,劳汉昌.整合素α_vβ_3和VEGF在骨折愈合过程中的表达及意义[J].中国矫形外科杂志,2012,20(2):165-168. 被引量：8
  • 9Reumann MK, Nair T, Strachna O,et al. Production of VEGF receptor 1 and 2 mRNA and protein during endochondral bone repair is differ- eutial and, healug pha specitc 1- I Appl Pkysl ( 1985 ) ,2010, 109(6) :1930 - 1938.
  • 10Sarahrudi K, Thomas A, Braunsteiner T, et al. VEGF serum concen- trations in patients with long hone fractures: a comparison between impaired and normal fracture healing [ J ]. J Orthop Res, 2009,27 (10) :1293 - 1297.

二级参考文献18

  • 1王晓滨,王伟.骨折修复中的血管新生[J].中国矫形外科杂志,2006,14(12):939-940. 被引量：6
  • 2Geris L,Gerisch A,Sloten JV,et al.Angiogenesis in bone fracture healing:a bioregulatory model[J].J Theor Biol,2008,1:137-158.
  • 3Hankenson KD,Dishowitz M,Gray C,et al.Angiogenesis in bone re-generation[J].Injury,2011,6:556-561.
  • 4Bauer SM,Bauer RJ,Velazquez OC,et al.Angiogenesis,vasculogene-sis,and induction of healing in chronic wounds[J].Vasc Endovascu-lar Surg,2005,4:293-306.
  • 5Carano RA,Filvaroff EH.Angiogenesis and bone repair[J].Drug Discov Today,2003,21:980-989.
  • 6Oxboel J,Binderup T,Knigge U,et al.Quantitative gene-expression of the tumor angiogenesis markers vascular endothelial growth factor,in-tegrin alphaV and integrin beta3in human neuroendocrine tumors[J].Oncol Rep,2009,3:769-775.
  • 7Bahar H,Benayahu D,Yaffe A,et al.Molecular signaling in bone re-generation[J].Crit Rev Eukaryot Gene Expr,2007,2:87-101.
  • 8Oxboel J,Binderup T,Knigge U,et al.Quantitative gene-expression of the tumor angiogenesis markers vascular endothelial growth factor,in-tegrin alphaV and integrin beta3in human neuroendocrine tumors[J].Oncol Rep.2009,3:769-775.
  • 9Kohno S,Kaku H,Tsutsui K,et al.Expression of vascular endothelial growth factor and the effects on bone remodeling during experimental tooth movement[J].J Dent Res,2003,3:177-182.
  • 10Robinson SD,Reynolds LE,Kostourou V,et al.Alphav beta3integrin limits the contribution of neuropilin-1to vascular endothelial growth factor-induced angiogenesis[J].J Biol Chem,2009,49:33966-33981.

共引文献30

同被引文献232

引证文献17

二级引证文献89

中国矫形外科杂志
2015年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部