摘要
孤独症研究所采用的动物模型包括基于可疑突变基因构建的动物模型和基于环境影响因素构建的动物模型.近交系BTBR小鼠自身的行为学表型与孤独症的三大核心临床症状一致,表现为低的社交行为,异常的超声波发声行为,高度重复的自我理毛行为,是孤独症研究较好的动物模型.愈来愈多的研究利用BTBR小鼠动物模型进行药物靶标的筛选.现对BTBR小鼠在孤独症研究中的进展作一介绍.
Several of the genetic models and environmental risk factor models were used in the animal model study in autism.The BTBR T＋ Itpr3tf（BTBR） mice are an inbred strain and have emerged as strong candidates to serve as models of a range of autism-relevant behaviors, showing deficiencies in social behaviors and reduced or unusual ultrasonic vocalizations as well as increased repetitive self-grooming.There are increasing investigations targeted to ameliorating the behavioral phenotypes of autism in BTBR mice.This review briefly summarizes the advance in the research on the BTBR mice model of autism.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2015年第24期1918-1920,共3页
Chinese Journal of Applied Clinical Pediatrics
基金
国家自然科学基金（81201061）
2014年度人力资源和社会保障部留学回国人员科技活动择优资助项目（2014）
山西省青年科技研究基金（2013021036-2）
山西省回国留学人员科研资助项目（2013-124）
