还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝损伤76例临床观察

76 cases of clinical observation of glutathione combine with polyene phosphatidylcholine in treatment of alcoholic liver injury

目的观察还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝损伤的临床疗效及安全性。方法选取我院2014年6~12月期间收治的酒精性肝损伤患者76例,随机分成治疗组和对照组各38例,治疗组给予注射用还原型谷胱甘肽联合多烯磷脂酰胆碱注射液静脉滴注,对照组给予注射用还原型谷胱甘肽联合复方甘草酸苷注射液静脉滴注,比较两组患者的临床疗效及安全性。结果治疗组在治疗后的总有效率、肝功能指标及肝纤维化指标改善方面明显高于对照组,且未发生明显不良反应,两组比较差异有统计学意义（P〈0.05）。结论还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝损伤疗效确切,安全性好,值得临床推广使用。

Objective To observe clinical curative effect and safety of glutathione combine with polyene phosphatidylcholine in treatment of alcoholic liver injury. Methods 76 patients with alcoholic liver injury who were admitted to our hospital from June 2014 to December 2014 were selected and they were allocated to the treatment group and the control group,with 38 in each.The treatment group was received intravenous drip of glutathione for injection combined with polyene phosphatidylcholine injection.The control group was received intravenous drip of glutathione for injection combined with compound glycyrrhizin injection.Clinical curative effect and safety of patients in two groups were compared. Results Total effective rate,liver function index and improvement of liver fibrosis indexes were significantly higher than those of the control group and there was no adverse reaction.There were significant statistical differences when two groups were compared（P〈0.05）. Conclusion Glutathione combine with polyene phosphatidylcholine in treatment of alcoholic liver injury has accurate curative effect and good safety,which is worthy of clinical promotion and application.