不同剂量艾贝宁对全麻拔管期血流动力学及躁动的影响

Effects of different doses of dexmedetomidine on hemodynamics and agitation during tracheal extubation of general anesthesia

目的比较不同剂量艾贝宁用于全身麻醉苏醒拔管期对患者的影响。方法 90例择期行广泛全子宫切除术的全麻手术患者分为对照组、低剂量组、高剂量组,每组30例,低剂量组应用0.3μg/kg艾贝宁,高剂量组应用1μg/kg艾贝宁,对照组应用等量生理盐水,比较三组拔管期间血流动力学、Narcotrend值、苏醒时间、躁动评分。结果与对照组相比较,高剂量组应用艾贝宁10 min后直至拔管后MAP均较低、苏醒时间较长、躁动发生率低,差异有统计学意义(P<0.05)。低剂量组血流动力学平稳,苏醒及拔管时间短,躁动发生率较低,差异有统计学意义(P<0.05)。结论低剂量艾贝宁用于全身麻醉苏醒拔管期可减少血流动力学波动,减少躁动,缩短拔管时间。

Objective To evaluate the effects of different doses of dexmedetomidine during tracheal extubation after general anesthesia. Methods Ninety cases of patients received radical hysterectomy surgery under general anesthesia were collected and divided into 3 groups（n =30 each）,control group,low-dose group and high-dose group. The low-dose group received 0.3 μg / kg dexmedetomidine. The high-dose group received 1 μg / kg dexmedetomidine. The control group received the e qual doses of saline. Hemodynamic changes, narcotrend value, recovery time and incidence of agitation were recorded during tracheal extubation after general anesthesia. Results Compared with control group, MAP of the patients in high-dose group were lower, recovery time were longer,incidence of agitation were lower（P〈0.05）. The hemodynamic changes of the low-dose group were more stable than the control group,the incidence of agitation were lower, recovery time and extubation time were shorter in low-dose group（P〈0.05）. Conclusion Low-dose dexmedetomidine for general anesthesia can effectively reduce extubation hemodynamic changes and incidence of agitation, and can shorten extubation time.