阿片类药物对乳腺癌血管生成及休眠的影响

The effects of opioids on breast cancer angiogenesis and dormancy

在乳腺癌综合治疗中,外科手术治疗占有重要地位,由此导致围术期镇痛药物的使用不可缺少。在围术期镇痛以及包括癌性疼痛在内的多种疼痛的治疗中,阿片类药物起着无可替代的作用,故部分乳腺癌患者在治疗过程中需使用阿片类药物。然而阿片类药物可能影响乳腺癌血管生成以及肿瘤细胞休眠、复发、转移,进而有可能影响乳腺癌患者的预后。因此,阿片类药物对于乳腺癌复发转移方面的影响不容忽视。

The incidence of breast cancer in our country is increasing in recent years. Surgical treatment occupies an important position in the comprehensive therapy of breast cancer,resulting in the use of perioperative analgesic drugs. Opioids are widely used in the perioperative analgesic and a variety of pain treatment, including cancerous pain. Opioids play an irreplaceable role in analgesia, so the use of opioids in the process of treatment is inevitable. However, the study found that opioids may affect breast cancer angiogenesis, tumor dormancy, recurrence and metastasis, which may affect the outcome of patients with breast cancer. Therefore, the effects of opioids on tumor recurrence and metastasis in patients with breast cancer cannot be ignored.