可必特、普米克令舒和万托林联合雾化吸入治疗COPD急性加重期患者的临床疗效观察

Clinical efficacy of aerosol inhalation of combivent,oulmicort respules and ventolin in treatment of COPD in acute exacerbation period

目的观察慢性阻塞性肺疾病(COPD)急性加重期患者可必特、普米克令舒和万托林联合雾化吸入治疗的临床效果。方法将80例COPD急性加重期患者随机分为治疗组和对照组,各组40例,对照组给予茶碱、糖皮质激素等常规治疗;治疗组在对照组治疗基础上雾化吸入可必特、普米克令舒和万托林。观察并比较2组患者的临床效果,症状、体征消失时间,静脉糖皮质激素使用量和使用天数,以及药物不良反应。结果治疗8天后,治疗组患者的临床效果明显优于对照组,差异有统计学意义(P<0.05);治疗组患者喘息、胸闷、气急症状及肺部哮鸣音消失时间均早于对照组(P<0.05);治疗组静脉使用糖皮质激素量明显少于对照组,且不良反应较轻(P<0.05);治疗后,2组肺功能均得到改善,且治疗组改善情况均优于对照组,差异均有统计学意义(P<0.05)。结论对于COPD急性加重期患者早期给予可必特、普米克令舒和万托林联合雾化吸入治疗起效快,疗效显著,不良反应少,并能减少静脉糖皮质激素使用量,具有较高的有效性及安全性。

Objective To observe the clinical efficacy of aerosol inhalation of combivent,pulmicort respules and ventolin in treatment of COPD in acute exacerbation period. Methods A total of 80 COPD cases with acute exacerbation were randomly divided into treatment group and control group,with 40 cases in each group. The control group received aminophylline and glucocorticoid intravenously,while the treatment group received aerosol inhalation of combivent,pulmicort respules and ventolin on the basis of the control group. The clinical efficacy,the time of disappearance of symptoms and wheezing sound,the glucocorticoid dosage and the incidence of adverse reactions of two groups were compared. Results The clinical efficacy in the treatment group was significantly better than that in the control group after 8 days（ P〈0. 05）. The duration of wheezing,chest distress,breathlessness and extinction time of wheezing sound in the treatment group were shorter than that in the control group（ P〈0. 05）. The amount of intravenous glucocorticoid in treatment group was less than that in the control group,and the adverse action were less in the treatment group（ P〈0. 05）. After treatment,the pulmonary function of two groups were both improved and the treatment group was better than the control group（ P〈0. 05）. Conclusion The clinical efficacy of aerosol inhalation of combivent,pulmicort respules and ventolin in the treatment of COPD with acute exacerbation has rapid efficacy,which can also reduce the glucocorticoid dosage and the incidence of adverse reactions. It is proven to be safe and effective.