生长分化因子-15在不同阶段糖尿病肾病患者的临床意义

Clinical significance of growth differentiation factor-15 in different stages of patients with diabetic nephropathy

目的分析糖尿病肾病患者不同阶段生长分化因子-15(GDF-15)表达的变化及临床意义。方法抽取150例糖尿病肾病患者,包括50例白蛋白尿正常患者(A组)、50例少量白蛋白尿患者(B组)和50例大量白蛋白尿患者(C组)。行酶联免疫吸附试验检测3组血浆GDF-15水平。结果 3组患者GDF-15水平比较,差异有统计学意义(P<0.05)。单因素分析表明GDF-15与胆固醇、甘油三酯、低密度脂蛋白、尿素氮、尿白蛋白排泄率、肌酐、糖化血红蛋白正相关,而与高密度脂蛋白、肾小球滤过率负相关(P<0.05)。逐步回归分析表明GDF-15是尿白蛋白排泄率的独立影响因素之一(P<0.05)。结论 GDF-15与糖尿病肾病的发生与发展密切相关。

Objective To analysis the change and clinical significance of growth differentiation factor-15 in different stages of patients with diabetic nephropathy. Methods A total of 150 diabetic nephropathy patients were selected,including 50 patients with normal albuminuria（ group A）,50 patients with a small amount of albuminuria（ group B） and 50 patients with macroalbuminuria（ group C）. Enzyme linked immunosorbent assay was used to detect plasma GDF-15 level in the three groups. Results There was significant difference of GDF-15 level among the three groups（ P〈0.05）. Single factor correlation indicated that GDF-15 was positively correlated with systolic blood pressure,triglyceride,triglyceride,three low density lipoprotein,blood urea nitrogen,urinary albumin excretion rate,creatinine and glycosylated hemoglobin,and was negatively correlated with high density lipoprotein and glomerular filtration（ P〈0. 05）. The stepwise regression analysis indicated that GDF-15 was one of the independent factors for the urinary albumin excretion rate（ P〈0. 05）. Conclusion GDF-15 is closely related to the occurrence and development of diabetic nephropathy.