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SOCS-1、SOCS-3对T细胞亚群分化的调节和在血液肿瘤疾病中的作用研究进展 被引量：3

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摘要 细胞因子信号转导异常可引起多种疾病,包括血液病、过敏性疾病及自身免疫性疾病等。细胞因子信号传导抑制蛋白（suppressor of cytokine signaling,SOCS）家族是一类由细胞因子诱导产生并反馈性阻断细胞因子信号转导过程的负性调节因子。其中SOCS-1和SOCS-3是SOCS家族的重要分子,大量研究表明其可被多种炎症因子和抗炎因子诱导表达,并抑制多种免疫分子的信号传导。T细胞亚群在免疫应答和免疫调节方面发挥了关键作用。研究发现,SOCS-1、SOCS-3通过调节T细胞亚群的分化使其产生不同的免疫应答类型。
作者 曾晓红 王强
机构地区 四川医科大学临床医学院 四川省人民医院儿科
出处 《中国小儿血液与肿瘤杂志》 CAS 2015年第6期333-336,共4页 Journal of China Pediatric Blood and Cancer
基金 四川省卫生厅科学研究基金资助项目(30305030163)
关键词 SOCS T细胞亚群 SOCS-3 细胞因子 血液肿瘤 免疫应答 负性调节因子 信号转导 免疫调节 CYTOKINE
分类号 R733 [医药卫生—肿瘤]
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参考文献29

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二级参考文献15

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共引文献10

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二级引证文献12

中国小儿血液与肿瘤杂志
2015年 第6期

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