云南省通海县209例乙肝感染孕产妇所生儿童预防母婴传播效果分析

Analysis on the effect of prevention of mother-to-child transmission of hepatitis B virus among 209 children born-to hepatitis B virus infected pregnant women in Tonghai county Yunnan province

目的了解研究地区乙肝病毒感染孕产妇所生儿童接受预防乙肝母婴传播服务的效果,并比较不同干预措施的实施效果。方法由研究地区内医疗机构管理资料中筛选2008-2013年乙肝感染孕产妇,通过医院系统管理软件进行相关信息收集。回顾性调查云南省通海县通过孕产期保健服务发现的209例户籍乙肝病毒感染孕产妇所生儿童接受预防乙肝母婴传播干预措施（单一阻断措施和联合阻断措施）后,乙肝母婴传播阻断所取得的效果。应用SPSS17.0统计软件进行统计分析。结果 209例乙肝感染产妇所生儿童在出生后采用不同的乙肝阻断措施干预后,乙肝病毒母婴传播率为2.87%,采取单一阻断措施的发生率为10.87%,采取联合阻断措施的发生率为0.06%,两种阻断方式比较,差异具有统计学意义（χ~2=12.12,P〈0.01）。结论采取两种干预措施均能有效预防乙肝母婴传播,而联合干预措施效果更好。

Objective To understand the results of implement prevention of mother-to-child transmission（ PMTCT） of hepatitis B virus（ HBV） in research site and compare the effects of two different interventions. Methods Recruited HBV infected pregnant women from the management data of health facilities in research site from 2008- 2013. The data was collected through the hospital informantion system. The data of receiving interventions and effects for PMTCT among 209 children born-to pregnant women with HBV infection who were detected through antenatal care were collected retrospectively. SPSS 17. 0 software was used to analyze the data.Results The mother-to-child transmission（ MTCT） rate was 2. 87% among 209 children born-to pregnant women with HBV infection after receiving PMTCT intervention. The MTCT rate was 10. 87% among children receiving single intervention,while the MTCT rate was 0. 06% among those receiving combined intervention. The difference is significant（ χ~2= 12. 12,P 〈 0. 01）. Conclusions The two kinds of PMTCT interventions were both effective,however,the combined intervention was better.