2011-2014年辽宁省葫芦岛市预防梅毒母婴传播效果分析

Effectiveness of prevention of mother-to-child transmission of syphilis program during 2011-2014 in Huludao city,Liaoning province

目的了解辽宁省葫芦岛市孕产妇梅毒感染流行状况,评价预防梅毒母婴传播干预措施的实施效果。方法对2011-2014年辽宁省葫芦岛市孕产妇梅毒检测资料,阳性孕产妇及其所生儿童实施综合干预措施情况进行分析。结果2011-2014年间,孕产妇梅毒检测阳性率从0.1%增长至0.4%,呈逐年上升趋势（趋势χ~2=42.16,P〈0.001）,2011-2014年共发现147例梅毒感染者,其中36例选择终止妊娠,111例选择继续妊娠,治疗率为100%,规范治疗率为26.1%。梅毒感染孕产妇分娩的111例婴儿中,死胎2例、7天内死亡2例、失访1例。检测106例满18个月的幼儿,先天梅毒7例（6.3%）、失访3例,儿童随访率达到97.1%。结论葫芦岛市孕产妇梅毒检测阳性率呈逐年上升趋势,通过全面开展预防梅毒母婴传播工作和落实综合干预措施,加强感染孕产妇治疗服务和暴露儿童随访管理,有效降低了先天梅毒的发生危险性。

Objective To study the epidemic status of syphilis infection in pregnant women in Huludao City,Liaoning Province and to evaluate the effectiveness of the intervention measures for prevention of mother-to-child transmission of syphilis in order to identify potential problems and develop recommendations for future work. Methods To assess the implementation of comprehensive intervention measures with syphilis testing data of syphilis positive pregnant women and their children during 2011 to 2014 in Huludao city,Liaoning province. Results In this study,syphilis infection rates increased from 0. 1% in 2011 to 0. 4% in 2014 among pregnant women（ trend χ~2= 42. 16,P 〈 0. 001）. Thirty six of 147 infected women terminated the pregnancies and 111 women continued the pregnancies and received comprehensive intervention services. Among those infected women,2 had fetal death. Two of syphilis exposed children died within 7 days after birth and one was lost of follow-up. In the remaining 106 syphilis exposed children who completed the 18 months following up,7 had congenital syphilis,96 were syphilis negative,and 3 were lost of follow-up. Followup completion rate was 97. 1%. Conclusion The rates of syphilis infection in pregnant women in Huludao increased in recent years,however,comprehensive measures for prevention of mother-to-child transmission have been implemented and effective interventions and following up services are provided for infected pregnant women and their children to reduce the risk of congenital syphilis.